| The complex p25/Cdk5 kinase in neurofibrillary degeneration and neuronal death: the missing link to cell cycle. | |
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MedLine Citation:
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PMID: 17571276 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Emergence of the cell cycle hypothesis in neurodegenerative disease comes from the numerous lines of evidence showing a tight link between "cell cycle-like reactivation" and neuronal death. Terminally differentiated neurons remain in G0 phase and display, compared to proliferating cells, an opposite regulation pattern of cell cycle markers in that most of the key activators and inhibitors are respectively down- and up-regulated. It has been clearly established that any experimental attempt to force terminally differentiated neurons to divide ultimately leads to their death. Conversely, cell cycle blockade in experimental models of neuronal death is able to rescue neurons. Hence, cell cycle deregulation is certainly among mechanisms governing neuronal death. However, many questions remain unresolved, especially those related to which molecular mechanisms trigger cell cycle deregulation and how this deregulation leads to cell death. In the present review, we focus on neurodegeneration in Alzheimer's disease and discuss the cell cycle deregulation related to this neurodegenerative pathology. Finally, we emphasize the role of p25/Cdk5 kinase complex in this pathological process through retinoblastoma protein phosphorylation and derepression of E2F-responsive genes and other actors such as cdc2, cyclins, and MCM proteins. |
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Authors:
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Malika Hamdane; Luc Buée |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Biotechnology journal Volume: 2 ISSN: 1860-7314 ISO Abbreviation: Biotechnol J Publication Date: 2007 Aug |
Date Detail:
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Created Date: 2007-08-16 Completed Date: 2007-09-11 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 101265833 Medline TA: Biotechnol J Country: Germany |
Other Details:
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Languages: eng Pagination: 967-77 Citation Subset: IM |
Affiliation:
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INSERM, U837, Lille, France. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Apoptosis Brain / enzymology, pathology Cell Cycle Cell Cycle Proteins / metabolism* Cyclin-Dependent Kinase 5 / metabolism* Humans Nerve Tissue Proteins / metabolism Neurodegenerative Diseases / enzymology*, pathology* Neurofibrillary Tangles / metabolism*, pathology Neurons / metabolism*, pathology |
| Chemical | |
Reg. No./Substance:
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0/Cell Cycle Proteins; 0/Nerve Tissue Proteins; EC 2.7.1.37/CDK5 protein, human; EC 2.7.11.22/Cyclin-Dependent Kinase 5 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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