Document Detail

The complex contribution of NOS interneurons in the physiology of cerebrovascular regulation.
MedLine Citation:
PMID:  22907993     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Following the discovery of the vasorelaxant properties of nitric oxide (NO) by Furchgott and Ignarro, the finding by Bredt and coll. of a constitutively expressed NO synthase in neurons (nNOS) led to the presumption that neuronal NO may control cerebrovascular functions. Consequently, numerous studies have sought to determine whether neuraly-derived NO is involved in the regulation of cerebral blood flow (CBF). Anatomically, axons, dendrites, or somata of NO neurons have been found to contact the basement membrane of blood vessels or perivascular astrocytes in all segments of the cortical microcirculation. Functionally, various experimental approaches support a role of neuronal NO in the maintenance of resting CBF as well as in the vascular response to neuronal activity. Since decades, it has been assumed that neuronal NO simply diffuses to the local blood vessels and produce vasodilation through a cGMP-PKG dependent mechanism. However, NO is not the sole mediator of vasodilation in the cerebral microcirculation and is known to interact with a myriad of signaling pathways also involved in vascular control. In addition, cerebrovascular regulation is the result of a complex orchestration between all components of the neurovascular unit (i.e., neuronal, glial, and vascular cells) also known to produce NO. In this review article, the role of NO interneuron in the regulation of cortical microcirculation will be discussed in the context of the neurovascular unit.
Sonia Duchemin; Michaël Boily; Nataliya Sadekova; Hélène Girouard
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Publication Detail:
Type:  Journal Article     Date:  2012-08-09
Journal Detail:
Title:  Frontiers in neural circuits     Volume:  6     ISSN:  1662-5110     ISO Abbreviation:  Front Neural Circuits     Publication Date:  2012  
Date Detail:
Created Date:  2012-08-21     Completed Date:  2012-10-02     Revised Date:  2013-08-13    
Medline Journal Info:
Nlm Unique ID:  101477940     Medline TA:  Front Neural Circuits     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  51     Citation Subset:  -    
Department of Pharmacology, Université de Montréal Montreal, QC, Canada.
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