Document Detail


The complementary roles of deletion and regulation in transplantation tolerance.
MedLine Citation:
PMID:  12563298     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Neonatal tolerance of alloantigens was described in mice nearly half a century ago, but unfortunately, the translation of these early findings into the clinical arena proved to be much more challenging than was first anticipated. However, the past decade has seen considerable progress in our understanding of the mechanisms that contribute to transplantation tolerance in experimental models. This review outlines our current understanding of the mechanisms of allograft tolerance, emphasizing the complementary roles of deletion and regulation of alloreactive T cells.
Authors:
Robert I Lechler; Oliver A Garden; Laurence A Turka
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Nature reviews. Immunology     Volume:  3     ISSN:  1474-1733     ISO Abbreviation:  Nat. Rev. Immunol.     Publication Date:  2003 Feb 
Date Detail:
Created Date:  2003-02-03     Completed Date:  2003-03-21     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  101124169     Medline TA:  Nat Rev Immunol     Country:  England    
Other Details:
Languages:  eng     Pagination:  147-58     Citation Subset:  IM    
Affiliation:
Department of Immunology, Division of Medicine, Imperial College of Science, Technology and Medicine, Hammersmith Campus, Commonwealth Building, Du Cane Road, London W12 0NN, UK. r.lechler@ic.ac.uk
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MeSH Terms
Descriptor/Qualifier:
Animals
Graft Rejection / etiology,  immunology
Humans
Immune Tolerance*
Immunosuppression
Isoantigens
Mice
Minor Histocompatibility Antigens
Models, Immunological
T-Lymphocytes / immunology
Transplantation Immunology*
Chemical
Reg. No./Substance:
0/Isoantigens; 0/Minor Histocompatibility Antigens

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