Document Detail


The complement system in ischemia-reperfusion injuries.
MedLine Citation:
PMID:  22964228     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Tissue injury and inflammation following ischemia and reperfusion of various organs have been recognized for many years. Many reviews have been written over the last several decades outlining the role of complement in ischemia/reperfusion injury. This short review provides a current state of the art knowledge on the complement pathways activated, complement components involved and a review of the clinical biologics/inhibitors used in the clinical setting of ischemia/reperfusion. This is not a complete review of the complement system in ischemia and reperfusion injury but will give the reader an updated view point of the field, potential clinical use of complement inhibitors, and the future studies needed to advance the field.
Authors:
William B Gorsuch; Elvina Chrysanthou; Wilhelm J Schwaeble; Gregory L Stahl
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Publication Detail:
Type:  Journal Article; Review     Date:  2012-08-07
Journal Detail:
Title:  Immunobiology     Volume:  217     ISSN:  1878-3279     ISO Abbreviation:  Immunobiology     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-09-11     Completed Date:  2013-03-14     Revised Date:  2013-11-06    
Medline Journal Info:
Nlm Unique ID:  8002742     Medline TA:  Immunobiology     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  1026-33     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier GmbH. All rights reserved.
Affiliation:
Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
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MeSH Terms
Descriptor/Qualifier:
Complement Activation*
Complement System Proteins / immunology*,  metabolism
Humans
Inflammation / immunology
Reperfusion Injury / immunology*
Grant Support
ID/Acronym/Agency:
R01 AI089781/AI/NIAID NIH HHS; R01 HL056086/HL/NHLBI NIH HHS; R56 AI089781/AI/NIAID NIH HHS; R56 HL056086/HL/NHLBI NIH HHS; RC1 HL099130/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
9007-36-7/Complement System Proteins
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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