Document Detail

The complement system at the fetomaternal interface.
MedLine Citation:
PMID:  16129961     Owner:  NLM     Status:  MEDLINE    
The placenta has a unique structural organization that allows fetal cells expressing paternal alloantigens to establish a peaceful cohabitation with the maternal immune system. The fetal cells are continuously exposed to the humoral and cellular components of the maternal immune system present in the maternal blood that circulates in the intervillous space and in the decidual vessels. This review deals with the role played by the complement system at the placental level both in physiological and pathological conditions of pregnancies. Complement components found in the placental tissue derive to a large extent from blood circulating in placental vessels. However, some complement components may also be produced locally by macrophages and other cell types. Deposition of complement components at tissue level is usually found in association with inflammatory diseases. This is not the case in placentae in which deposits of complement components can also be documented in physiological conditions not resulting in fetal damage. Protection of the semiallogenic human conceptus against maternal complement activation products is achieved by surface expression of complement regulators that act at different steps of the complement sequence. These complement regulators are localized in a strategic position on the surface of villous trophoblast protecting the fetus from the damage that may derive from uncontrolled complement activation. However, pathological conditions of pregnancies may lead to deposition of a higher amount of complement activation products that may exceed the protection of local complement regulators.
Roberta Bulla; Fleur Bossi; Fabio Fischetti; Francesco De Seta; Francesco Tedesco
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Chemical immunology and allergy     Volume:  89     ISSN:  1660-2242     ISO Abbreviation:  Chem Immunol Allergy     Publication Date:  2005  
Date Detail:
Created Date:  2005-08-30     Completed Date:  2005-11-02     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  101183835     Medline TA:  Chem Immunol Allergy     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  149-57     Citation Subset:  IM    
Department of Physiology and Pathology, IRCCS Burlo Garofolo, University of Trieste, Trieste, Italy.
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MeSH Terms
Complement Activation
Complement System Proteins / metabolism*
Immune Tolerance
Maternal-Fetal Exchange / immunology*
Placenta / immunology*
Pregnancy Complications / immunology
Reg. No./Substance:
0/Isoantigens; 9007-36-7/Complement System Proteins

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