| The complement C1qA enhances retinoic acid-inducible gene-I-mediated immune signalling. | |
| | |
MedLine Citation:
|
PMID: 22260551 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The cellular innate immune response is essential for recognizing and defending against viral infection. Retinoic acid-inducible gene-I (RIG-I) and virus-induced signaling adaptor (VISA) mediated immune signalling is critically involved in RNA-virus-induced innate immune responses. Here we demonstrate that the complement C1qA interacts with different RIG-I pathway components and enhances RIG-I-VISA-mediated signalling pathway as well as TBK1-mediated activation of interferon-β (IFN-β) promoter. Our data show that over-expression of C1qA up-regulates RIG-I-mediated activation of IFN-stimulated responsive element (ISRE) and nuclear factor-κB reporters and IFN-β transcription, but not IFN regulatory factor-3-mediated and inhibitor of κB kinase-mediated activation of ISRE and nuclear factor-κB promoter. In addition, C1qA can counteract the function of the C1q receptor gC1qR in RIG-I-mediated signalling. Our results reveal the important role of complement C1qA in the innate immune response. |
| | |
Authors:
|
Yetao Wang; Xiaomei Tong; Junjie Zhang; Xin Ye |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Immunology Volume: 136 ISSN: 1365-2567 ISO Abbreviation: Immunology Publication Date: 2012 May |
Date Detail:
|
Created Date: 2012-04-04 Completed Date: 2012-05-16 Revised Date: 2013-05-02 |
Medline Journal Info:
|
Nlm Unique ID: 0374672 Medline TA: Immunology Country: England |
Other Details:
|
Languages: eng Pagination: 78-85 Citation Subset: IM |
Copyright Information:
|
© 2012 The Authors. Immunology © 2012 Blackwell Publishing Ltd. |
Affiliation:
|
Centre for Molecular Immunology, CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Cell Line Complement C1q / immunology* DEAD-box RNA Helicases / genetics, immunology*, metabolism Dogs Humans Immunity, Innate Interferon-beta / immunology, metabolism NF-kappa B / immunology, metabolism Signal Transduction* |
| Chemical | |
Reg. No./Substance:
|
0/NF-kappa B; 77238-31-4/Interferon-beta; 80295-33-6/Complement C1q; EC 3.6.1.-/DDX58 protein, human; EC 3.6.1.-/DEAD-box RNA Helicases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Structure refinement of protein low resolution models using the GNEIMO constrained dynamics method.
Next Document: 'Out-patient' albumin dialysis for cholestatic patients with intractable pruritus.