| The complement C1qA enhances RIG-I mediated immune signaling. | |
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MedLine Citation:
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PMID: 22260551 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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The cellular innate immune response is essential for recognizing and defending against viral infection. RIG-I and VISA mediated immune signaling is critically involved in RNA virus induced innate immune responses. Here we demonstrate that the complement C1qA interacts with different RIG-I pathway components and enhances RIG-I-VISA mediated signaling pathway as well as TBK1 mediated activation of IFN-β promoter. Our data show that ovexpression of C1qA upregulates RIG-I mediated activation of ISRE and NF-κB reporters and IFN-β transcription, but not IRF-3 and IKK-β mediated activation of ISRE and NF-κB promoter. In addition, C1qA can counteract with the function of C1q receptor gC1qR in RIG-I mediated signaling. Our results reveal the important role of complement C1qA in innate immune response. |
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Authors:
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Yetao Wang; Xiaomei Tong; Junjie Zhang; Xin Ye |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-1-19 |
Journal Detail:
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Title: Immunology Volume: - ISSN: 1365-2567 ISO Abbreviation: - Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2012-1-20 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0374672 Medline TA: Immunology Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Journal compilation © 2012 Blackwell Publishing Ltd. |
Affiliation:
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Center for Molecular Immunology, CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences (CAS), Beijing 100101, P. R. China Graduate University of Chinese Academy of Sciences, Beijing 100101, China. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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