Document Detail

The compensation of post-traumatic oedema in the rabbit at different ages.
MedLine Citation:
PMID:  4840847     Owner:  NLM     Status:  MEDLINE    
1. The compensation of fluid loss from the circulation after an LD(50) period of bilateral hind-limb ischaemia in a thermoneutral environment has been studied in the rabbit from birth until young adulthood.2. The fluid loss from the circulation was calculated from the increase in the great vessel haematocrit value as the red cell volume and F(cells) were unchanged after limb ischaemia. This ;apparent' fluid loss was compared with the ;actual' fluid loss calculated from the increase in water content of the injured limbs.3. The 0- to 1-day-old rabbit was better able to restore fluid, and protein, to the circulation than the older animal and suffered a smaller percentage reduction in arterial blood pressure after an LD(50) period of ischaemia.4. The better compensation of post-traumatic fluid loss during the first 48 hr of life may be explained by the high capillary filtration coefficient and the post-traumatic increase in plasma protein osmotic pressure found at that age.5. The more efficient restoration of the plasma volume by the 0- to 1-day-old rabbit may account for the increased ability to withstand post-traumatic fluid loss at that age.
R A Little
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of physiology     Volume:  238     ISSN:  0022-3751     ISO Abbreviation:  J. Physiol. (Lond.)     Publication Date:  1974 Apr 
Date Detail:
Created Date:  1974-09-19     Completed Date:  1974-09-19     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0266262     Medline TA:  J Physiol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  207-21     Citation Subset:  IM    
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MeSH Terms
Age Factors
Animals, Newborn
Blood Pressure
Blood Proteins / analysis
Blood Volume*
Capillary Permeability
Edema / physiopathology*
Hindlimb / blood supply
Muscles / blood supply
Osmotic Pressure
Time Factors
Reg. No./Substance:
0/Blood Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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