| A compartmental model for the bicoid gradient. | |
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MedLine Citation:
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PMID: 20580703 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The anterior region of the Drosophila embryo is patterned by the concentration gradient of the homeodomain transcription factor bicoid (Bcd). The Bcd gradient was the first identified morphogen gradient and continues to be a subject of intense research at multiple levels, from the mechanisms of RNA localization in the oocyte to the evolution of the Bcd-mediated patterning events in multiple Drosophila species. Critical assessment of the mechanisms of the Bcd gradient formation requires biophysical models of the syncytial embryo. Most of the proposed models rely on reaction-diffusion equations, but their formulation and applicability at high nuclear densities is a nontrivial task. We propose a straightforward alternative in which the syncytial blastoderm is approximated by a periodic arrangement of well-mixed compartments: a single nucleus and an associated cytoplasmic region. We formulate a compartmental model, constrain its parameters by experimental data, and demonstrate that it provides an adequate description of the Bcd gradient dynamics. |
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Authors:
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Michail E Kavousanakis; Jitendra S Kanodia; Yoosik Kim; Ioannis G Kevrekidis; Stanislav Y Shvartsman |
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Publication Detail:
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Type: Journal Article Date: 2010-05-24 |
Journal Detail:
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Title: Developmental biology Volume: 345 ISSN: 1095-564X ISO Abbreviation: Dev. Biol. Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-08-10 Completed Date: 2010-09-15 Revised Date: 2011-09-26 |
Medline Journal Info:
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Nlm Unique ID: 0372762 Medline TA: Dev Biol Country: United States |
Other Details:
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Languages: eng Pagination: 12-7 Citation Subset: IM |
Copyright Information:
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Copyright 2010 Elsevier Inc. All rights reserved. |
Affiliation:
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Department of Chemical Engineering, Princeton University, Princeton, NJ, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Algorithms Animals Blastoderm / cytology, embryology, metabolism Body Patterning / genetics, physiology* Drosophila / embryology*, genetics Embryo, Nonmammalian / cytology, embryology*, metabolism Female Gene Expression Regulation, Developmental Homeodomain Proteins / genetics, physiology* Male Models, Biological* Oocytes / cytology, metabolism RNA, Messenger / genetics, metabolism Trans-Activators / genetics, physiology* |
| Grant Support | |
ID/Acronym/Agency:
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R01 GM078079-04/GM/NIGMS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Homeodomain Proteins; 0/RNA, Messenger; 0/Trans-Activators; 0/bicoid protein, Drosophila |
| Comments/Corrections | |
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