| A compartment model for percutaneous absorption: compatibility of lag time and steady-state flux with diffusion model. | |
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MedLine Citation:
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PMID: 1432629 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The lag times and steady-state flux predicted by a specific case of the compartment model, which was recently proposed to generate finite-dose percutaneous permeation pharmacokinetics, are compared with those predicted by the diffusion model. When the intercompartmental transfer rate constants are defined so that the three statistical moments of the compartmental model (the mean residence times of a drug in the vehicle and that in the skin and the variance of residence time in the vehicle) are identical to those in the diffusion model, the lag times and steady-state flux values predicted by the two models are the same. |
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Authors:
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K Kubota; H I Maibach |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of pharmaceutical sciences Volume: 81 ISSN: 0022-3549 ISO Abbreviation: J Pharm Sci Publication Date: 1992 Sep |
Date Detail:
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Created Date: 1992-12-10 Completed Date: 1992-12-10 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 2985195R Medline TA: J Pharm Sci Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 863-5 Citation Subset: IM |
Affiliation:
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Department of Dermatology, University of California, San Francisco, School of Medicine 94143-0989. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Diffusion Humans Models, Biological* Skin Absorption* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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