Document Detail


A comparison of wound healing between a skin protectant ointment and a medical device topical emulsion after laser resurfacing of the perioral area.
MedLine Citation:
PMID:  21247664     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
BACKGROUND: Currently, there is no standard of care for postlaser resurfacing treatment of the face. Ideally, treatment should speed re-epithelialization and reduce downtime, with minimal irritation. OBJECTIVE: This study compared the wound healing efficacy and safety of Aquaphor Healing Ointment (AHO) (Beiersdorf Inc, Wilton, CT) and Biafine Topical Emulsion (BTE) (OrthoNeutrogena, Los Angeles, CA) treatment after laser resurfacing of the perioral area. METHODS: In this double-blind, split-face study, 20 subjects with perioral rhytides received fractional carbon dioxide laser resurfacing. AHO and BTE were applied to opposite sides of the face 4 times daily after the resurfacing procedure. Clinical grading of erythema, edema, epithelial confluence, crusting/scabbing, subjective irritation, and general wound appearance were assessed using 5-point scales on days 2, 4, 7, and 14. Subjects ranked the two treatment sites daily as to which side of their face looked better. RESULTS: AHO resulted in significantly less erythema (days 2 and 7) and crusting/scabbing (days 2, 4, and 7) and higher epithelial confluence (day 4) than BTE (P ≤ .042). Subjective irritation assessments demonstrated significantly less stinging, itching, and tightness at day 2 and tightness at day 7 with AHO than with BTE (P ≤ .049). General wound appearance was graded significantly higher for AHO on days 2 and 7 (P ≤ .049). Significantly more subjects preferred AHO to BTE (P ≤ .046). LIMITATIONS: This was a small study in a homogenous population of white women. CONCLUSIONS: AHO exhibited superiority to BTE in several wound healing parameters and in overall wound condition.
Authors:
Deborah S Sarnoff
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-1-17
Journal Detail:
Title:  Journal of the American Academy of Dermatology     Volume:  -     ISSN:  1097-6787     ISO Abbreviation:  -     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2011-1-20     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7907132     Medline TA:  J Am Acad Dermatol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2010 American Academy of Dermatology, Inc. Published by Mosby, Inc. All rights reserved.
Affiliation:
Cosmetique Dermatology, Laser and Plastic Surgery LLP, New York, New York.
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