Document Detail


A comparison of vascular inflammation in psoriasis, rheumatoid arthritis, and healthy subjects by FDG-PET/CT: a pilot study.
MedLine Citation:
PMID:  24224139     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: Psoriasis (PSO) and rheumatoid arthritis (RA) increase cardiovascular diseases (CVD) beyond traditional risk factors. Vascular inflammation has previously been demonstrated to be present in PSO and RA using [18F]-fluorodeoxyglucose-positron emission tomography/computed tomography (FDG-PET/CT) imaging. However, vascular inflammation has not been compared in these two disorders relative to a healthy reference population. Thus, vascular inflammation was quantitatively assessed in patients with PSO (n=10), RA (n=5), and healthy subjects (n=10) using FDG-PET/CT.
METHODS: FDG-PET/CT mean standardized uptake value (SUVmean) was determined slice by slice within the ascending, aortic arch, descending thoracic, suprarenal abdominal, and infrarenal abdominal aorta, and the mean metabolic volumetric product (MVPmean) was then calculated for each aortic subsegment. Plasma lipids and metabolic and inflammatory markers were also assessed.
RESULTS: CVD risk profiles were largely similar across groups. After adjustment for CV risk factors, regional aortic vascular inflammation based on MVPmean was elevated for both PSO (beta coefficients 0.31-1.47, p<0.001) and RA (beta coefficients 0.15-0.69, p<0.05) compared to healthy subjects.
CONCLUSIONS: These observations using FDG-PET/CT to estimate vascular inflammation support epidemiological findings of premature atherosclerosis in PSO and RA. The use of FDG-PET/CT to investigate vascular inflammation across systemic inflammatory diseases warrants further examination in larger study populations.
Authors:
Shawn Rose; Nikhil H Sheth; Joshua F Baker; Alexis Ogdie; Anna Raper; Babak Saboury; Thomas J Werner; Preethi Thomas; Abby Vanvoorhees; Abass Alavi; Drew A Torigian; Joel M Gelfand; Nehal N Mehta
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Publication Detail:
Type:  Journal Article     Date:  2013-11-01
Journal Detail:
Title:  American journal of cardiovascular disease     Volume:  3     ISSN:  2160-200X     ISO Abbreviation:  Am J Cardiovasc Dis     Publication Date:  2013  
Date Detail:
Created Date:  2013-11-13     Completed Date:  2013-11-13     Revised Date:  2014-10-10    
Medline Journal Info:
Nlm Unique ID:  101569582     Medline TA:  Am J Cardiovasc Dis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  273-8     Citation Subset:  -    
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Descriptor/Qualifier:
Grant Support
ID/Acronym/Agency:
R01 HL111293/HL/NHLBI NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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