| A comparison of two regimens of misoprostol for second trimester medical termination of pregnancy: a randomized trial. | |
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MedLine Citation:
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PMID: 20555044 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The objective of this study was to compare the efficacy and side-effects of two regimens of vaginal misoprostol for second trimester voluntary medical termination of pregnancy (MTP) according to the MTP Act of India. A randomized trial was conducted in 185 women from January 2007 to September 2008. Women in group 1 were given vaginal misoprostol 400 microg every 6 h for a maximum of four doses. Women in group 2 were given vaginal misoprostol 400 microg every 12 h for a maximum of four doses. Our primary outcome measure was induction abortion interval. Secondary outcome measures were success rate, side-effects and completeness of procedure. Results were calculated applying Fisher's exact test, chi-square test, Z test and calculating the P value using an alpha level of 0.05 for Type I error. The mean induction abortion interval in group 1 (12.59 h) was significantly shorter (P < 0.001) than that in the group 2 (16.41 h). The percentage of women who achieved successful abortion within 12 h in group 1 (56.52%) was also significantly higher (P = 0.00005) than that in group 2 (25.80%). The incidence of side-effects was comparable and not clinically serious. It is concluded that the regimen of vaginal misoprostol 400 microg every 6 h was more effective than the regimen of misoprostol every 12 h in medical termination of second trimester pregnancy. |
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Authors:
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Snehamay Chaudhuri; Pradip Kumar Banerjee; Malay Mundle; Sankar Nath Mitra |
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Publication Detail:
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Type: Comparative Study; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: Tropical doctor Volume: 40 ISSN: 1758-1133 ISO Abbreviation: Trop Doct Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-06-17 Completed Date: 2010-08-03 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 1301706 Medline TA: Trop Doct Country: England |
Other Details:
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Languages: eng Pagination: 144-8 Citation Subset: IM |
Affiliation:
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Department of Gynaecology & Obstetrics, NRS Medical College, Kolkata, 138 AJC Bose Road, Kolkata-700014, West Bengal, India. snehamay_chaudhuri_dr@yahoo.com |
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| MeSH Terms | |
Descriptor/Qualifier:
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Abortifacient Agents, Nonsteroidal
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administration & dosage*,
adverse effects Abortion, Induced / methods* Administration, Intravaginal Adolescent Adult Dose-Response Relationship, Drug Drug Administration Schedule Female Gestational Age Humans India Misoprostol / administration & dosage*, adverse effects Pregnancy Pregnancy Trimester, Second Prospective Studies Treatment Outcome Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Abortifacient Agents, Nonsteroidal; 59122-46-2/Misoprostol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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