Document Detail

A comparison of two regimens of misoprostol for second trimester medical termination of pregnancy: a randomized trial.
MedLine Citation:
PMID:  20555044     Owner:  NLM     Status:  MEDLINE    
The objective of this study was to compare the efficacy and side-effects of two regimens of vaginal misoprostol for second trimester voluntary medical termination of pregnancy (MTP) according to the MTP Act of India. A randomized trial was conducted in 185 women from January 2007 to September 2008. Women in group 1 were given vaginal misoprostol 400 microg every 6 h for a maximum of four doses. Women in group 2 were given vaginal misoprostol 400 microg every 12 h for a maximum of four doses. Our primary outcome measure was induction abortion interval. Secondary outcome measures were success rate, side-effects and completeness of procedure. Results were calculated applying Fisher's exact test, chi-square test, Z test and calculating the P value using an alpha level of 0.05 for Type I error. The mean induction abortion interval in group 1 (12.59 h) was significantly shorter (P < 0.001) than that in the group 2 (16.41 h). The percentage of women who achieved successful abortion within 12 h in group 1 (56.52%) was also significantly higher (P = 0.00005) than that in group 2 (25.80%). The incidence of side-effects was comparable and not clinically serious. It is concluded that the regimen of vaginal misoprostol 400 microg every 6 h was more effective than the regimen of misoprostol every 12 h in medical termination of second trimester pregnancy.
Snehamay Chaudhuri; Pradip Kumar Banerjee; Malay Mundle; Sankar Nath Mitra
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Publication Detail:
Type:  Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Tropical doctor     Volume:  40     ISSN:  1758-1133     ISO Abbreviation:  Trop Doct     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-06-17     Completed Date:  2010-08-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  1301706     Medline TA:  Trop Doct     Country:  England    
Other Details:
Languages:  eng     Pagination:  144-8     Citation Subset:  IM    
Department of Gynaecology & Obstetrics, NRS Medical College, Kolkata, 138 AJC Bose Road, Kolkata-700014, West Bengal, India.
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MeSH Terms
Abortifacient Agents, Nonsteroidal / administration & dosage*,  adverse effects
Abortion, Induced / methods*
Administration, Intravaginal
Dose-Response Relationship, Drug
Drug Administration Schedule
Gestational Age
Misoprostol / administration & dosage*,  adverse effects
Pregnancy Trimester, Second
Prospective Studies
Treatment Outcome
Young Adult
Reg. No./Substance:
0/Abortifacient Agents, Nonsteroidal; 59122-46-2/Misoprostol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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