Document Detail

A comparison of two epidural alpha 2-agonists, guanfacine and clonidine, in regard to duration of antinociception, and ventilatory and hemodynamic effects in goats.
MedLine Citation:
PMID:  1567040     Owner:  NLM     Status:  MEDLINE    
Epidural clonidine produces analgesia in humans with acute and chronic pain. Its use is limited because of short-lasting analgesia, hemodynamic depression, sedation, and respiratory depression. Intrathecal guanfacine has a longer duration of action than intrathecal clonidine. The present study compares these two drugs administered epidurally. Pulmonary artery, carotid artery, and epidural catheters were inserted into five goats. Each animal received guanfacine 5 mg/10 mL, clonidine 750 micrograms/10 mL, or a 10-mL saline control solution on separate occasions. Antinociception (tested via a point pressure stimulation device), arterial blood pressure, heart rate, cardiac output, pulmonary capillary wedge pressure, and arterial and mixed venous blood gases were measured every 30 min for 8 h. Guanfacine produced a longer duration of antinociception (guanfacine = 8 h vs clonidine = 5.5 h). Increases in PaCO2 were more pronounced in the clonidine group. There were no marked hemodynamic differences between the two drugs. Pretreatment with epidural idazoxan, an alpha 2-antagonist, blocked the antinociceptive effects of guanfacine. Because of a longer duration of action and less respiratory depression, epidural guanfacine may be superior for postoperative analgesia and chronic pain syndromes.
B D Smith; L J Baudendistel; J J Gibbons; J F Schweiss
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Anesthesia and analgesia     Volume:  74     ISSN:  0003-2999     ISO Abbreviation:  Anesth. Analg.     Publication Date:  1992 May 
Date Detail:
Created Date:  1992-05-21     Completed Date:  1992-05-21     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  1310650     Medline TA:  Anesth Analg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  712-8     Citation Subset:  AIM; IM    
Department of Anesthesiology, St. Louis University, Missouri.
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MeSH Terms
Clonidine / administration & dosage,  therapeutic use*
Drug Evaluation, Preclinical
Guanfacine / administration & dosage,  therapeutic use*
Hemodynamics / drug effects*
Injections, Epidural
Pain / drug therapy*
Respiration / drug effects*
Time Factors
Reg. No./Substance:
29110-47-2/Guanfacine; 4205-90-7/Clonidine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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