| A comparison of triple combination cream and hydroquinone 4% cream for the treatment of moderate to severe facial melasma. | |
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MedLine Citation:
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PMID: 17348994 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The aim of this study was to compare the efficacy and safety of a triple combination (TC) cream and monotherapy with hydroquinone (HQ) cream in the treatment of moderate to severe facial melasma. A total of 120 patients applied TC cream once daily or HQ cream twice daily for 8 weeks. Evaluations included static global severity assessment of melasma, improvement of melasma over time, local tolerability, and adverse events. TC cream was significantly more effective than HQ cream from week 4 onwards: lesions were approximately equivalent to the surrounding skin in 35% of all TC-treated patients, compared to 5% of those who used HQ cream (P = 0.0001). Improvement of more than 75% was achieved by 73% of TC cream patients and 49% of HQ cream patients (P = 0.007). The incidence of adverse events (erythema, burning sensation, and desquamation) was similar in both groups. No patient dropped out of the study because of drug-related adverse events. TC cream was more effective than the HQ cream for the treatment of moderate to severe facial melasma. Both products had similar safety profiles. |
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Authors:
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Tania Ferreira Cestari; Karime Hassun; Alexandre Sittart; Maria de Lourdes Viegas |
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Publication Detail:
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Type: Comparative Study; Journal Article; Multicenter Study; Randomized Controlled Trial |
Journal Detail:
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Title: Journal of cosmetic dermatology Volume: 6 ISSN: 1473-2165 ISO Abbreviation: J Cosmet Dermatol Publication Date: 2007 Mar |
Date Detail:
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Created Date: 2007-03-12 Completed Date: 2007-03-29 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101130964 Medline TA: J Cosmet Dermatol Country: England |
Other Details:
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Languages: eng Pagination: 36-9 Citation Subset: IM |
Affiliation:
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Department of Dermatology, Federal University of Rio Grande do Sul--Hospital de Clinicas de Porto Alegre, Porto Alegre, Brazil. tcestari@hcpa.ufrgs.br |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Topical Adult Drug Combinations Emollients Facial Dermatoses / diagnosis, drug therapy* Female Fluocinolone Acetonide / therapeutic use* Follow-Up Studies Humans Hydroquinones / administration & dosage* Male Melanosis / diagnosis, drug therapy* Middle Aged Probability Reference Values Severity of Illness Index Single-Blind Method Treatment Outcome Tretinoin / therapeutic use* |
| Chemical | |
Reg. No./Substance:
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0/Drug Combinations; 0/Emollients; 0/Hydroquinones; 123-31-9/hydroquinone; 302-79-4/Tretinoin; 67-73-2/Fluocinolone Acetonide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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