Document Detail

A comparison of topical acyclovir with steroids in the treatment of herpes zoster keratouveitis.
MedLine Citation:
PMID:  6357273     Owner:  NLM     Status:  MEDLINE    
Topical acyclovir has been compared with topical steroids in a coded controlled trial of the treatment of keratouveitis caused by herpes zoster in 40 patients. Topical acyclovir was significantly superior to topical steroids in terms of treatment duration (75 days to 280 days), with no recurrences after the patients were weaned off treatment; there was a 63% recurrence rate in the steroid group. Corneal epithelial disease resolved significantly quicker in the acyclovir treated group. If recurrences occurred in the steroid group, other parts of the eye not initially affected were also involved. Treatment of such recurrences was more difficult than treatment of the initial attack.
J McGill; C Chapman
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  The British journal of ophthalmology     Volume:  67     ISSN:  0007-1161     ISO Abbreviation:  Br J Ophthalmol     Publication Date:  1983 Nov 
Date Detail:
Created Date:  1984-01-07     Completed Date:  1984-01-07     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0421041     Medline TA:  Br J Ophthalmol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  746-50     Citation Subset:  IM    
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MeSH Terms
Acyclovir / therapeutic use*
Administration, Topical
Betamethasone / therapeutic use*
Clinical Trials as Topic
Double-Blind Method
Herpes Zoster Ophthalmicus / drug therapy*
Keratitis / drug therapy*
Uveitis / drug therapy*
Reg. No./Substance:
378-44-9/Betamethasone; 59277-89-3/Acyclovir

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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