| A comparison of tibolone and hormone replacement therapy on coronary artery and myocardial function in ovariectomized atherosclerotic monkeys. | |
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MedLine Citation:
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PMID: 11791085 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: Tibolone is used to prevent osteoporosis and to treat climacteric symptoms. The objectives of these studies were to measure and compare the effects of tibolone with hormone replacement therapy on coronary artery vascular reactivity and myocardial function and to relate these outcomes to treatment-induced plasma lipid/lipoprotein concentrations and atherosclerosis. DESIGN: One hundred forty-eight adult ovariectomized cynomolgus monkeys were fed an atherogenic diet for 24 months while receiving one of five oral treatments: no treatment (control, n = 31); conjugated equine estrogens (CEE), given at the equivalent of 0.625 mg/day ( n = 27); CEE (same dose) plus medroxyprogesterone acetate (MPA), given at the equivalent of 2.5 mg/day ( n = 29); low-dose tibolone (LoTib; 0.625 mg/day equivalent, n = 30); or high-dose tibolone (HiTib; 2.5 mg/day equivalent, n = 31). RESULTS: Quantitative coronary angiography showed that endothelium-mediated dilation was enhanced (17.5 +/- 5%, p = 0.002) in the CEE-treated group (but not other treatment groups) compared with the control. Both doses of tibolone and CEE reduced the incidence of dobutamine-induced ST-segment depression (LoTib: 33%, HiTib 25%, and CEE: 23%) compared to the control (79%) ( p = <0.05). Neither vascular reactivity nor dobutamine-induced myocardial ischemia were associated with treatment-induced changes in atherosclerosis or plasma lipid/lipoprotein concentrations. CONCLUSIONS: Tibolone, unlike CEE, has no benefit for endothelium-mediated dilation. Despite these differences, both tibolone and CEE reduced the incidence of myocardial ischemia, whereas CEE+MPA had no effect. It is speculated that tibolone may have direct effects on the myocardium that protect against myocardial ischemia. |
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Authors:
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J Koudy Williams; Jason Hall; Mary S Anthony; Thomas C Register; Steven E Reis; Thomas B Clarkson |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Menopause (New York, N.Y.) Volume: 9 ISSN: 1072-3714 ISO Abbreviation: Menopause Publication Date: 2002 Jan-Feb |
Date Detail:
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Created Date: 2002-01-15 Completed Date: 2002-03-14 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 9433353 Medline TA: Menopause Country: United States |
Other Details:
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Languages: eng Pagination: 41-51 Citation Subset: IM |
Affiliation:
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The Comparative Medicine Clinical Research Center, Wake Forest University School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157-1040, USA. kwilliam@wfubmc.edu |
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Arteries / drug effects* Coronary Artery Disease / drug therapy Dobutamine / administration & dosage, adverse effects Drug Therapy, Combination Estrogen Receptor Modulators / pharmacology* Estrogens, Conjugated (USP) / blood, pharmacology* Female Heart / drug effects* Infusions, Intravenous Lipoproteins / blood, drug effects Macaca fascicularis Medroxyprogesterone Acetate / pharmacology Myocardial Ischemia / chemically induced, drug therapy Norpregnenes / blood, pharmacology* Ovariectomy |
| Grant Support | |
ID/Acronym/Agency:
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R01 AG 16742/AG/NIA NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Estrogen Receptor Modulators; 0/Estrogens, Conjugated (USP); 0/Lipoproteins; 0/Norpregnenes; 34368-04-2/Dobutamine; 5630-53-5/tibolone; 71-58-9/Medroxyprogesterone Acetate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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