Document Detail

A comparison of target-controlled therapy with patient-controlled administration of propofol combined with midazolam for sedation during dental surgery.
MedLine Citation:
PMID:  12622106     Owner:  NLM     Status:  MEDLINE    
Forty anxious day case patients undergoing extraction of third molar teeth under local anaesthesia with sedation, were studied in a randomised double-blind controlled trial. A target-controlled infusion of propofol was compared with patient-controlled propofol for sedation, combined with a small dose of midazolam to improve amnesia. The objectives of the study were to measure the total dose of propofol used by the two groups and assess recovery and patient satisfaction. The mean dose of propofol used in the patient-controlled sedation group was significantly less than the target-controlled group (p < 0.00007). Five patients became over-sedated in the target-controlled group compared with none in the patient-controlled group. Only one of the three tests of performance showed that the target-controlled patients were more sedated. Patient satisfaction was high in both groups despite a greater recollection of events in the patient-controlled group.
R Burns; A F McCrae; B Tiplady
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Anaesthesia     Volume:  58     ISSN:  0003-2409     ISO Abbreviation:  Anaesthesia     Publication Date:  2003 Feb 
Date Detail:
Created Date:  2003-03-06     Completed Date:  2003-03-25     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0370524     Medline TA:  Anaesthesia     Country:  England    
Other Details:
Languages:  eng     Pagination:  170-6     Citation Subset:  AIM; IM    
Department of Anaesthetics, Royal Infirmary of Edinburgh, UK.
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MeSH Terms
Ambulatory Surgical Procedures
Anesthesia, Dental / methods*
Anesthesia, Local
Conscious Sedation / methods*
Double-Blind Method
Drug Combinations
Hemodynamics / drug effects
Hypnotics and Sedatives*
Molar, Third / surgery
Patient Satisfaction
Self Administration
Tooth Extraction*
Reg. No./Substance:
0/Drug Combinations; 0/Hypnotics and Sedatives; 2078-54-8/Propofol; 59467-70-8/Midazolam

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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