Document Detail

A comparison of the systemic responses to rapid intravenous injections of ioxilan, iohexol, and diatrizoate in rabbits.
MedLine Citation:
PMID:  2745009     Owner:  NLM     Status:  MEDLINE    
Rapid intravenous injections of contrast media are used for angiocardiography, intravenous digital subtraction angiography (DSA), and rapid scan computed tomography procedures. These rapid intravenous injections have been shown to produce significant hemodynamic changes that appear related to contrast media osmolality. In this study the systemic responses to 2-second injections at a dose of 1.5 mL/kg were compared for a new nonionic agent, ioxilan (350 mgI/mL), and for iohexol (350 mgI/mL), meglumine/sodium diatrizoate (370 mgI/mL), and saline. Ioxilan has a lower osmolality and viscosity than iohexol and is formulated with a 3 mM sodium citrate as a buffer and anticoagulant. All of the test solutions produced statistically significant changes in arterial pressure and respiratory rate (P less than .05, Student's t-test). The decrease in arterial pressure seen with diatrizoate (20.1%) was significantly greater than the decrease seen with either ioxilan (10.2%) or iohexol (10.2%). All of the responses observed were transient and would not be of clinical concern in a healthy patient. Ioxilan, which contains the calcium binding agent, sodium citrate, and iohexol appear to cause less systemic effects then diatrizoate.
T W Morris; L Prentice; J Ventura
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Investigative radiology     Volume:  24     ISSN:  0020-9996     ISO Abbreviation:  Invest Radiol     Publication Date:  1989 Apr 
Date Detail:
Created Date:  1989-08-25     Completed Date:  1989-08-25     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0045377     Medline TA:  Invest Radiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  294-7     Citation Subset:  IM    
Department of Diagnostic Radiology, University of Rochester Medical Center, New York 14642.
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MeSH Terms
Contrast Media / administration & dosage*
Diatrizoate Meglumine / administration & dosage*
Hemodynamics / drug effects*
Injections, Intravenous
Iohexol / administration & dosage*,  analogs & derivatives*
Osmolar Concentration
Time Factors
Grant Support
Reg. No./Substance:
0/Contrast Media; 107793-72-6/ioxilan; 131-49-7/Diatrizoate Meglumine; 66108-95-0/Iohexol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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