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A comparison of survival and secondary contraction in expanded versus conventional full-thickness skin grafts: an experimental study in rats.
MedLine Citation:
PMID:  22582117     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
Aim: The aim of this experimental study is based on a comparison between the effect of expanded versus nonexpanded full-thickness skin grafts (FTSGs) on survival and secondary wound contraction. Methods: A total of 20 quadrangular-shaped, full-thickness skin defects with dimensions of 2 × 3 cm were created on the backs of 10 rats. Two groups were specified in this study depending on the coverage of the aforementioned defect areas using expanded versus conventional full-thickness grafts (n = 10 per group). The survival area of each graft and the amount of graft/wound contraction (secondary contraction) were measured by computerized planimetry on days 0, 7, 30, and 90. Results: The mean graft areas achieved were 5.8 ± 0.6, 4.2 ± 1.5, and 1.2 ± 1.1 cm(2) (P < .001) in the expanded FTSGs group and 5.3 ± 0.9, 3.3 ± 1.3, and 0.98 ± 0.8 cm(2) (P < .001) in the nonexpanded FTSGs group on days 7, 30, and 90, respectively. Graft area reductions (secondary contraction) were 1.7 ± 0.9 and 2.1 ± 1.2 cm(2) (P = .8) on day 30 and 2.1 ± 1.3 and 2.86 ± 0.8 cm(2) (P = .3) on day 90 in the expanded and nonexpanded groups, respectively. Conclusion: According to this study, FTSGs that were harvested from tissue expansion revealed biological behaviors that were comparable with those of conventional grafts.
Authors:
As'adi Kamran; Fatemi Mohammad Javad; Fazeli Sahram; Mousavi Seyed Jaber
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Publication Detail:
Type:  Journal Article     Date:  2012-04-24
Journal Detail:
Title:  Eplasty     Volume:  12     ISSN:  1937-5719     ISO Abbreviation:  Eplasty     Publication Date:  2012  
Date Detail:
Created Date:  2012-05-14     Completed Date:  2012-08-23     Revised Date:  2013-04-05    
Medline Journal Info:
Nlm Unique ID:  101316107     Medline TA:  Eplasty     Country:  United States    
Other Details:
Languages:  eng     Pagination:  e20     Citation Subset:  -    
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