Document Detail

A comparison of survival between radiosurgery and stereotactic implants for malignant astrocytomas.
MedLine Citation:
PMID:  7717135     Owner:  NLM     Status:  MEDLINE    
The purpose of this paper is to compare the survival of three groups of patients with high grade supratentorial gliomas who were treated on three sequential protocols with surgical resection, external beam fractionated radiotherapy and a boost to the residual contrasting enhancing mass by either interstitial brachytherapy (IB, n = 33), by interstitial thermoradiotherapy (IT, n = 25) or by stereotactic radiosurgery (SRS, n = 19). The primary aim of this study was to evaluate the role of different boosting techniques in the initial management of primary brain tumors. External beam radiotherapy doses were escalated from one study to the next so that the median doses given to the IB, the IT, and the SRS groups were 41.4 Gy, 48.4 Gy, and 59.4 Gy, respectively. The median dose of interstitial irradiation or stereotactic radiosurgery, were 40 Gy, 32.2 Gy and 10 Gy, respectively, for the same groups. Follow-up was such that all living patients had been followed for a minimum of 30, 27, 4 months in the IB, IT, and SRS groups, respectively; hence, twelve-month survival was 52% (95% CI: 34%-69%), 80% (95% CI: 64%-96%), and 51% (95% CI: 24%-78%) in the same respective groups. Using a multivariate Cox proportional hazards model, treatment with IT conferred a survival advantage over IB (p = 0.029). Furthermore, survival of patients treated with SRS did not significantly differ from that of patients treated with an implant with or without hyperthermia.(ABSTRACT TRUNCATED AT 250 WORDS)
B Stea; K Rossman; J Kittelson; B Lulu; A Shetter; J R Cassady; A Hamilton
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Acta neurochirurgica. Supplement     Volume:  62     ISSN:  0065-1419     ISO Abbreviation:  Acta Neurochir. Suppl.     Publication Date:  1994  
Date Detail:
Created Date:  1995-05-17     Completed Date:  1995-05-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  100962752     Medline TA:  Acta Neurochir Suppl     Country:  AUSTRIA    
Other Details:
Languages:  eng     Pagination:  47-54     Citation Subset:  IM    
Department of Radiation Oncology, University of Arizona Health Sciences Center, Tucson, USA.
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MeSH Terms
Brain / pathology,  surgery*
Glioma / pathology,  surgery*,  therapy
Hyperthermia, Induced
Middle Aged
Retrospective Studies
Stereotaxic Techniques*
Supratentorial Neoplasms / pathology,  surgery*,  therapy

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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