Document Detail


A comparison of sucralfate and prednisolone enemas in the treatment of active distal ulcerative colitis.
MedLine Citation:
PMID:  2688065     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Sucralfate is well established in the treatment of upper gastrointestinal inflammation and ulceration, and preliminary evidence suggests it may be of benefit in active colitis. We have therefore undertaken a clinical trial to compare enemas of sucralfate (4 g) and prednisolone metasulphobenzoate (20 mg) in the treatment of active distal ulcerative colitis. Forty-four patients were entered into a 4-week study. Two patients were withdrawn because of non-compliance, and five were unable to complete the study: two developed constipation (both allocated to sucralfate) and three were unable to retain the enemas (two prednisolone and one sucralfate). Intention-to-treat analysis showed significant within-treatment improvement in rectal bleeding, sigmoidoscopic grade, and histologic grade in the prednisolone-treated group, and in stool frequency, rectal bleeding, and sigmoidoscopic grade in the sucralfate-treated group. Between-treatment comparisons, however, showed greater resolution of rectal bleeding and more marked improvements in histologic grade in patients treated with prednisolone metasulphobenzoate enemas. Further studies using higher doses of sucralfate would be useful.
Authors:
S A Riley; I Gupta; V Mani
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Scandinavian journal of gastroenterology     Volume:  24     ISSN:  0036-5521     ISO Abbreviation:  Scand. J. Gastroenterol.     Publication Date:  1989 Oct 
Date Detail:
Created Date:  1990-01-25     Completed Date:  1990-01-25     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0060105     Medline TA:  Scand J Gastroenterol     Country:  NORWAY    
Other Details:
Languages:  eng     Pagination:  1014-8     Citation Subset:  IM    
Affiliation:
Dept. of Gastroenterology, Leigh Infirmary, Greater Manchester, England.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Clinical Trials as Topic
Colitis, Ulcerative / drug therapy*
Double-Blind Method
Enema
Female
Humans
Male
Middle Aged
Prednisolone / therapeutic use*
Prognosis
Prospective Studies
Sucralfate / therapeutic use*
Chemical
Reg. No./Substance:
50-24-8/Prednisolone; 54182-58-0/Sucralfate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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