Document Detail

A comparison study of local injection and radiofrequency ablation therapy for traumatic portal vein injure guided by contrast-enhanced ultrasonography.
MedLine Citation:
PMID:  22345343     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: To compare local injection of hemostatic agents and radiofrequency (RF)-assisted hemostasis in the management of bleeding from the portal vein with varying diameters and blood flow velocities.
MATERIAL AND METHODS: Sixteen Bama pigs were used. Laparotomy was performed to expose the liver and inner diameters and blood flow velocities of the pre-injured portal vein in the hepatic segments and subsegments were measured. Vascular injuries in the portal vein were produced (4 in each pig). The pigs were randomly divided into two groups and local injection of hemostatic agents was performed in one group and RF-assisted hemostasis in the other, both techniques monitored by contrast-enhanced ultrasonography (CEUS). Time to hemostasis was measured, and the extent of liver injury was determined 2 h after treatment.
RESULTS: In the local injection group, the rates of successful hemostasis were 100, 88.9, and 50% with portal veins with inner diameters of < 1 mm, 1-2 mm, and 2-3 mm, respectively, and the maximum time to achieve hemostasis was 24.0 ± 7.2 s. Hemostasis was not successful when the diameter was > 3 mm. In the RF-assisted group, hemostasis was successfully at all sites regardless of vessel diameter; however, the maximum time to achieve hemostasis was 156.8 ± 31.2 s. Injury to surrounding tissue was significantly greater in the RF-assisted group.
CONCLUSION: Both methods can achieve hemostasis with small diameter portal vein injuries; however, RF-assisted hemostasis is necessary for larger vessels, though it is associated with greater damage to surrounding tissue.
Yukun Luo; Qiang Liu; Ziyu Jiao; Rong Wu; Jie Tang; Faqin Lv
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Annals of hepatology     Volume:  11     ISSN:  1665-2681     ISO Abbreviation:  Ann Hepatol     Publication Date:    2012 Mar-Apr
Date Detail:
Created Date:  2012-02-20     Completed Date:  2012-07-17     Revised Date:  2013-05-16    
Medline Journal Info:
Nlm Unique ID:  101155885     Medline TA:  Ann Hepatol     Country:  Mexico    
Other Details:
Languages:  eng     Pagination:  249-56     Citation Subset:  IM    
Department of Ultrasound, Chinese People's Liberation Army General Hospital, Beijing 100853, China.
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MeSH Terms
Batroxobin / therapeutic use*
Catheter Ablation / methods*
Hemostatic Techniques
Hemostatics / therapeutic use*
Injections / methods*
Portal Vein / injuries*,  ultrasonography
Treatment Outcome
Ultrasonography, Interventional / methods
Vascular Surgical Procedures / methods*
Reg. No./Substance:
0/Hemostatics; EC 3.4.21.-/Batroxobin

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