| A comparison of statistical methods for combining event rates from clinical trials. | |
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MedLine Citation:
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PMID: 2704896 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We compare two statistical methods for combining event rates from several studies. Both methods treat each study as a separate stratum. The Peto-modified Mantel-Haenszel (Peto) method estimates a combined odds ratio assuming homogeneity across strata and provides a test for heterogeneity. The DerSimonian and Laird modified Cochran method (D&L) produces a weighted average of rate differences, where the weights allow for among-study variability. We analyse 22 meta-analyses from ten reports by both methods. The pooled estimates are divided by their standard errors to produce a Z-statistic. A t-test comparing Z-statistics from all 22 studies suggests that the D&L method tends to be more conservative [d(Peto - D&L) = 0.29, t = 2.53, p = 0.02]. For a subset of 14 non-heterogeneous studies, the difference is smaller and non-significant (d = 0.09, t = 0.72, p = 0.49). The results from the methods correlate well (r = 0.66 for all 22 studies, r = 0.95 for 14 non-heterogeneous studies). Thus, the presence of heterogeneity influences our conclusion. We discuss the statistical and scientific implications of these findings. |
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Authors:
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J A Berlin; N M Laird; H S Sacks; T C Chalmers |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Statistics in medicine Volume: 8 ISSN: 0277-6715 ISO Abbreviation: Stat Med Publication Date: 1989 Feb |
Date Detail:
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Created Date: 1989-05-16 Completed Date: 1989-05-16 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8215016 Medline TA: Stat Med Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 141-51 Citation Subset: IM |
Affiliation:
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New England Research Institute, Watertown, MA 02172. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Clinical Trials as Topic
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statistics & numerical data* Data Interpretation, Statistical* Humans Meta-Analysis as Topic* |
| Grant Support | |
ID/Acronym/Agency:
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CA-35291/CA/NCI NIH HHS; GM-29745/GM/NIGMS NIH HHS; LM-03116/LM/NLM NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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