| A comparison of single-voxel clinical in vivo hepatic (31) P MR spectra acquired at 1.5 and 3.0 Tesla in health and diseased states. | |
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MedLine Citation:
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PMID: 20949641 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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With the increasing availability of human MR scanners at various field strengths, the optimal field strength for in vivo clinical MR studies of the liver has become a focus of attention. Comparison between results at 3.0 and 1.5 T is of particular clinical interest, especially for multicentre studies. For MRS studies, higher field strengths should be advantageous, because improved sensitivity and chemical shift dispersion are expected. We report a comparison between single-voxel hepatic proton-decoupled (31) P MRS performed at 1.5 and 3.0 T in the same subjects using similar methodologies. Twelve healthy volunteers and 15 patients with chronic liver disease were studied. Improved spectral resolution was achieved using proton decoupling, and there was an improvement (21%) in the signal-to-noise ratio (SNR) of the phosphomonoester (PME) resonance at 3.0 T relative to 1.5 T. There was no significant change in nuclear Overhauser effects for PME or phosphodiesters (PDEs) between the two field strengths. The T(1) value of PDE was significantly longer at 3 T, although there was no significant change in the T(1) value of PME. There was no significant difference in the mean PME/PDE ratios for either the control or patient groups at both 1.5 and 3.0 T, but there was a small positive mean difference in PME/PDE at 3.0 T on pairwise testing between field strengths (+ 0.05, p < 0.01). There were significant correlations between PME/PDE values at the two magnetic field strengths (r = 0.806, p < 0.001). The underlying broad resonance was reduced at 3.0 T relative to 1.5 T, related to line broadening of the phospholipid bilayer signal. In conclusion, there was an improvement in hepatic (31) P MR signal quality at 3.0 T relative to 1.5 T. Broadly similar hepatic (31) P MR parameters were obtained at 1.5 and 3.0 T. The modest difference noted in the PME/PDE ratio between field strengths for patients with chronic liver disease should inform multicentre study design involving these field strengths. Copyright © 2010 John Wiley & Sons, Ltd. |
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Authors:
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Marzena Wylezinska; Jeremy F L Cobbold; Julie Fitzpatrick; Mark J W McPhail; Mary M E Crossey; Howard C Thomas; Joseph V Hajnal; William Vennart; I Jane Cox; Simon D Taylor-Robinson |
Publication Detail:
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Type: Journal Article Date: 2010-10-15 |
Journal Detail:
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Title: NMR in biomedicine Volume: 24 ISSN: 1099-1492 ISO Abbreviation: NMR Biomed Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-03-15 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8915233 Medline TA: NMR Biomed Country: England |
Other Details:
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Languages: eng Pagination: 231-7 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 John Wiley & Sons, Ltd. |
Affiliation:
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Hepatology and Gastroenterology Section, Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, St Mary's Campus, Faculty of Medicine, Imperial College London, London, UK; Biological Imaging Centre, Imaging Sciences Department, Division of Clinical Sciences, Hammersmith Campus, Faculty of Medicine, Imperial College London, London, UK. |
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