Document Detail

A comparison of seven prothrombin time reagents--development of an evaluation strategy.
MedLine Citation:
PMID:  3237706     Owner:  NLM     Status:  MEDLINE    
The control of p.o. anticoagulant therapy by the use of prothrombin times or ratios is one of the major functions of a clinical coagulation laboratory. European prothrombin reagents tend to be more sensitive to the effects of p.o. anticoagulants than traditional North American rabbit brain thromboplastin reagents. The clinical importance of this in vitro observation has been emphasized by the results of two recent clinical trials which both suggested that the less intense anticoagulation therapy that results from the use of a European-type prothrombin reagent may be safer. To minimize the clinical effects of differences in prothrombin time reagent formulation, a global correction factor has been developed--the international normalized ratio (INR). Despite this advance in international standardization, individual laboratories need a rapid and efficient method to help select the most appropriate prothrombin reagent for the clinical management of their local patient population. This study has examined the response of a variety of commercially available prothrombin time reagents to normal plasmas and those from anticoagulated patients. Using both classical sampling theory and multiple range testing, it was demonstrated that as few as 20 estimations on normal plasmas and 50 on anticoagulated specimens will permit a clinical laboratory to select a suitable prothrombin time reagent for anticoagulant control of their specific local patient population.
C J Carter; D J Griswold; R A Louis; R Hershler; L D Wadsworth
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc     Volume:  1     ISSN:  0893-3952     ISO Abbreviation:  Mod. Pathol.     Publication Date:  1988 Jul 
Date Detail:
Created Date:  1989-05-11     Completed Date:  1989-05-11     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8806605     Medline TA:  Mod Pathol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  284-7     Citation Subset:  IM    
Department of Pathology, University of British Columbia, Canada.
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MeSH Terms
Anticoagulants / pharmacology*
Evaluation Studies as Topic
Prothrombin Time*
Reagent Kits, Diagnostic / standards*
Reference Standards
Thromboplastin / analysis
Reg. No./Substance:
0/Anticoagulants; 0/Reagent Kits, Diagnostic; 9035-58-9/Thromboplastin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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