Document Detail


A comparison of serial 49-lead precordial ECG maps and standard 6-lead precordial ECGs in patients with acute anterior Q wave myocardial infarction.
MedLine Citation:
PMID:  2708928     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A comparison of 265 pairs of standard ECGs and 49-lead precordial maps in 20 patients with ST-segment elevations in anterior ECG leads on admission who eventually were diagnosed as having suffered an anterior Q wave myocardial infarction was carried out to investigate the diagnostic performance provided by the standard ECG in serial studies. Ten patients received intravenous methylprednisolone and 10 were given placebo on admission, and paired map-standard ECG studies were done. ST-segment elevations were taken as an index of ischemic injury and reduction of R wave amplitude or development of Q waves as a marker of developing necrosis. Methods of measurements and derivation of ECG parameters used in the analysis were the same for the standard ECGs and maps. Comparisons of percent change of five ECG-derived variables between 13 time points and admission, as assessed by the six precordial leads of the standard ECGs and the paired 49-lead maps, were made for the entire data base. A separate analysis to assess the performance of the standard ECG was carried out in a comparison of the methylprednisolone and placebo subgroups. In this latter assessment results of comparisons of the standard ECGs from the treatment and placebo cohorts were similar to the conclusions from the comparisons of the corresponding 49-lead maps. Comparisons for the entire 265 pairs of tracings by the two ECG systems demonstrated that the standard ECG is adequate to monitor quantitatively the ischemic injury and necrosis as reflected by the ECG in serial studies throughout the hospitalization and can be effectively employed in lieu of multilead precordial maps in the evaluation of therapeutic modalities for patients with anterior Q wave myocardial infarction.
Authors:
J E Madias
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Controlled Clinical Trial; Journal Article    
Journal Detail:
Title:  Journal of electrocardiology     Volume:  22     ISSN:  0022-0736     ISO Abbreviation:  J Electrocardiol     Publication Date:  1989 Apr 
Date Detail:
Created Date:  1989-06-02     Completed Date:  1989-06-02     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0153605     Medline TA:  J Electrocardiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  113-24     Citation Subset:  IM    
Affiliation:
Department of Medicine, Mount Sinai-City Hospital Center, Elmhurst, NY 11373.
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MeSH Terms
Descriptor/Qualifier:
Body Surface Area*
Data Interpretation, Statistical
Electrocardiography / methods*
Humans
Methylprednisolone / therapeutic use
Monitoring, Physiologic
Myocardial Infarction / drug therapy,  physiopathology*
Chemical
Reg. No./Substance:
83-43-2/Methylprednisolone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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