Document Detail

A comparison of selected antihypertensives and the use of conventional vs ambulatory blood pressure in the detection and treatment of hypertension.
MedLine Citation:
PMID:  11574740     Owner:  NLM     Status:  MEDLINE    
This multicenter, randomized, double-blind, parallel group study was undertaken to determine the effectiveness of selected antihypertensives (doxazosin, amlodipine, enalapril, and bendrofluazide) in maintaining 24-hour control of blood pressure (BP). The predictive value of ambulatory (A)BP versus clinic (C)BP measurements as a method for detecting patients with hypertension was also evaluated. A total of 204 patients were screened and of these 110 were diagnosed as mild to moderately hypertensive with clinic diastolic BP 100-110 mm Hg (> or =95 mm Hg in patients with coronary heart disease risk factors). The 4 antihypertensives were all equally effective at controlling BP over 24 h, as shown by 24-hour ABP measurements. The incidence of adverse events was similar for all 4 treatment groups; headache was the most common event, being reported by 22 patients (20%). There was a clinically relevant reduction in total cholesterol for the doxazosin (-15.4 mg/dl) and amlodipine (-11.6 mg/dl) treatment groups in comparison with enalapril and bendrofluazide. Our results from ABP measurements suggest that the antihypertensives studied are effective first-line therapy in the regulation of hypertension and that ABP is a reproducible measure. ABP may also be useful in identifying patients with various types of high BP, for instance those with 'white coat' hypertension, enabling more accurate screening and diagnosis.
D Ebbs
Publication Detail:
Type:  Clinical Trial; Journal Article; Multicenter Study; Randomized Controlled Trial    
Journal Detail:
Title:  Cardiology     Volume:  96 Suppl 1     ISSN:  0008-6312     ISO Abbreviation:  Cardiology     Publication Date:  2001  
Date Detail:
Created Date:  2001-09-27     Completed Date:  2001-12-20     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  1266406     Medline TA:  Cardiology     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  3-9     Citation Subset:  IM    
Copyright Information:
Copyright 2001 S. Karger AG, Basel
Didcot Health Centre, Didcot, Oxfordshire, UK.
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MeSH Terms
Amlodipine / therapeutic use
Analysis of Variance
Antihypertensive Agents / adverse effects,  therapeutic use*
Bendroflumethiazide / therapeutic use
Blood Pressure / drug effects*
Blood Pressure Determination / methods*
Blood Pressure Monitoring, Ambulatory
Diastole / drug effects
Double-Blind Method
Doxazosin / therapeutic use
Enalapril / therapeutic use
Hypertension / diagnosis*,  drug therapy*,  physiopathology
Middle Aged
Systole / drug effects
Treatment Outcome
Reg. No./Substance:
0/Antihypertensive Agents; 73-48-3/Bendroflumethiazide; 74191-85-8/Doxazosin; 75847-73-3/Enalapril; 88150-42-9/Amlodipine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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