| A comparison of the safety and intraocular pressure lowering of bimatoprost/timolol fixed combination versus latanoprost/timolol fixed combination in patients with open-angle glaucoma. | |
| | |
MedLine Citation:
|
PMID: 17519068 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
PURPOSE: To compare the efficacy and tolerability of a once daily evening dose of the latanoprost/timolol fixed combination (LTFC) with that of a once-daily evening dose of the bimatoprost/timolol fixed combination (BTFC) in patients with open-angle glaucoma with elevated intraocular pressure (IOP) insufficiently responsive to monotherapy with prostaglandin analogues/prostamides. DESIGN: Prospective, randomized, evaluator masked, single-center study. PARTICIPANTS: 36 patients with a diagnosis of open-angle glaucoma, with or without pseudoexfoliation, and inadequate control of IOP, insufficiently responsive to monotherapy with prostaglandin analogues/prostamides. MAIN OUTCOME MEASURE: The primary end-points were the change in IOP at 9:00 am from baseline to week 4, and the difference between treatment groups in the mean diurnal IOP reduction from baseline to week 4. RESULTS: BTFC provided significantly greater mean diurnal IOP reduction [mean (standard deviation)] 2.8 (0.9) mmHg, compared with LTFC 2.1 (0.6) mmHg, p = 0.0214. Both treatments significantly reduced the IOP from baseline at each IOP time-point measured, p < 0.0001, and for the mean diurnal IOP; p = 0.0049 for the LTFC, and p < 0.0001 for the BTFC. There were no significant differences in average hyperemia scores among groups, 1.25 (0.5) vs. 1.62 (0.69), p = 0.3835, for the LTFC and the BTFC, respectively. CONCLUSIONS: The results of this study showed a significantly higher IOP-lowering effect of a once-daily evening dose of the BTFC compared to that of a once-daily evening administration of the LTFC. |
| | |
Authors:
|
Antonio Martinez; Manuel Sanchez |
Related Documents
:
|
7523028 - Effects of endothelin-1 on intraocular pressure and aqueous humor dynamics in the rabbi... 6704008 - Effects of topical betaxolol in ocular hypertensive patients. 20840218 - Precision and accuracy of the icare tonometer - peripheral and central iop measurements... 7549448 - Systemic blood pressure and capillary blood-cell velocity in glaucoma patients: a preli... 8417398 - Genetic factors that predispose the child to develop hypertension. 10826398 - Association between alcohol intake and development of hypertension in japanese normoten... |
Publication Detail:
|
Type: Comparative Study; Journal Article; Randomized Controlled Trial |
Journal Detail:
|
Title: Current medical research and opinion Volume: 23 ISSN: 1473-4877 ISO Abbreviation: Curr Med Res Opin Publication Date: 2007 May |
Date Detail:
|
Created Date: 2007-05-23 Completed Date: 2007-07-26 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0351014 Medline TA: Curr Med Res Opin Country: England |
Other Details:
|
Languages: eng Pagination: 1025-32 Citation Subset: IM |
Affiliation:
|
Instituto Gallego de Oftalmología, Santiago de Compostela, La Coruña, Spain. tontxu_1999@yahoo.com |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Aged Aged, 80 and over Amides / administration & dosage*, adverse effects Antihypertensive Agents / administration & dosage, adverse effects Cloprostenol / administration & dosage, adverse effects, analogs & derivatives* Drug Combinations Female Glaucoma, Open-Angle / drug therapy* Humans Intraocular Pressure / drug effects* Lipids / administration & dosage*, adverse effects Male Middle Aged Prostaglandins F, Synthetic / administration & dosage*, adverse effects Single-Blind Method Timolol / administration & dosage*, adverse effects Treatment Outcome |
| Chemical | |
Reg. No./Substance:
|
0/Amides; 0/Antihypertensive Agents; 0/Drug Combinations; 0/Lipids; 0/Prostaglandins F, Synthetic; 0/bimatoprost; 130209-82-4/latanoprost; 26839-75-8/Timolol; 40665-92-7/Cloprostenol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: A 2-night, 3-period, crossover study of ramelteon's efficacy and safety in older adults with chronic...
Next Document: Randomized, double-blind, placebo-controlled clinical trial of loperamide plus simethicone versus lo...