Document Detail

A comparison of the safety and intraocular pressure lowering of bimatoprost/timolol fixed combination versus latanoprost/timolol fixed combination in patients with open-angle glaucoma.
MedLine Citation:
PMID:  17519068     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To compare the efficacy and tolerability of a once daily evening dose of the latanoprost/timolol fixed combination (LTFC) with that of a once-daily evening dose of the bimatoprost/timolol fixed combination (BTFC) in patients with open-angle glaucoma with elevated intraocular pressure (IOP) insufficiently responsive to monotherapy with prostaglandin analogues/prostamides. DESIGN: Prospective, randomized, evaluator masked, single-center study. PARTICIPANTS: 36 patients with a diagnosis of open-angle glaucoma, with or without pseudoexfoliation, and inadequate control of IOP, insufficiently responsive to monotherapy with prostaglandin analogues/prostamides. MAIN OUTCOME MEASURE: The primary end-points were the change in IOP at 9:00 am from baseline to week 4, and the difference between treatment groups in the mean diurnal IOP reduction from baseline to week 4. RESULTS: BTFC provided significantly greater mean diurnal IOP reduction [mean (standard deviation)] 2.8 (0.9) mmHg, compared with LTFC 2.1 (0.6) mmHg, p = 0.0214. Both treatments significantly reduced the IOP from baseline at each IOP time-point measured, p < 0.0001, and for the mean diurnal IOP; p = 0.0049 for the LTFC, and p < 0.0001 for the BTFC. There were no significant differences in average hyperemia scores among groups, 1.25 (0.5) vs. 1.62 (0.69), p = 0.3835, for the LTFC and the BTFC, respectively. CONCLUSIONS: The results of this study showed a significantly higher IOP-lowering effect of a once-daily evening dose of the BTFC compared to that of a once-daily evening administration of the LTFC.
Antonio Martinez; Manuel Sanchez
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Publication Detail:
Type:  Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Current medical research and opinion     Volume:  23     ISSN:  1473-4877     ISO Abbreviation:  Curr Med Res Opin     Publication Date:  2007 May 
Date Detail:
Created Date:  2007-05-23     Completed Date:  2007-07-26     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0351014     Medline TA:  Curr Med Res Opin     Country:  England    
Other Details:
Languages:  eng     Pagination:  1025-32     Citation Subset:  IM    
Instituto Gallego de Oftalmología, Santiago de Compostela, La Coruña, Spain.
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MeSH Terms
Aged, 80 and over
Amides / administration & dosage*,  adverse effects
Antihypertensive Agents / administration & dosage,  adverse effects
Cloprostenol / administration & dosage,  adverse effects,  analogs & derivatives*
Drug Combinations
Glaucoma, Open-Angle / drug therapy*
Intraocular Pressure / drug effects*
Lipids / administration & dosage*,  adverse effects
Middle Aged
Prostaglandins F, Synthetic / administration & dosage*,  adverse effects
Single-Blind Method
Timolol / administration & dosage*,  adverse effects
Treatment Outcome
Reg. No./Substance:
0/Amides; 0/Antihypertensive Agents; 0/Drug Combinations; 0/Lipids; 0/Prostaglandins F, Synthetic; 0/bimatoprost; 130209-82-4/latanoprost; 26839-75-8/Timolol; 40665-92-7/Cloprostenol

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