| The comparison of the responsiveness of human isolated internal mammary and gastroepiploic arteries to levcromakalim: an alternative approach to the management of graft spasm. | |
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MedLine Citation:
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PMID: 9241096 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIMS: We studied the effectiveness of levcromakalim, a potassium channel opener (KCO), in the prevention and reversal of spasm in arterial grafts used in coronary artery bypass operations, namely, internal mammary artery (IMA) and gastroepiploic artery (GEA). METHODS: Spasm was mimicked in vitro in arterial rings from 109 patients by increasing the vascular tension with noradrenaline, the thromboxane analogue U46619, endothelin-1 and K+. RESULTS: GEA displayed considerably higher contractile force to these agents than IMA. Pretreatment with levcromakalim depressed significantly the maximal contractile responses (either absolute or relative) to noradrenaline and U46619 but did not affect those of endothelin-1 and K+ in both of the arteries. Sensitivities (to all agents, except to endothelin-1) decreased significantly after levcromakalim. In experiments evaluating the antispasmodic activity of levcromakalim, a higher relaxant capacity was observed in GEA than IMA (for K+ contraction; IMA: 31.32 +/- 3.83%, n= 13 vs GEA: 98.01 +/- 0.71%, n=7, P<0.05). This different activity of levcromakalim between two arterial grafts was apparent even when GEA rings were contracted to higher force (g) than that of IMA (for K+ contraction; GEA: 72.56 +/- 4.96%, n = 7). Responses to levcromakalim were similar in IMA and GEA when endothelin-1 was used as the spasmogenic agent (IMA: 80.98 +/- 4.85%, n=10 vs GEA: 91.93 +/- 3.17%, n=7, P>0.05). CONCLUSIONS: Our results provide evidence that levcromakalim may have a therapeutic value in the treatment of spasm of coronary artery bypass grafts, especially GEA. |
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Authors:
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F Akar; B S Uydeş-Dogan; H Tufan; S Aşlamaci; C Köksoy; I Kanzik |
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Publication Detail:
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Type: Comparative Study; In Vitro; Journal Article |
Journal Detail:
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Title: British journal of clinical pharmacology Volume: 44 ISSN: 0306-5251 ISO Abbreviation: Br J Clin Pharmacol Publication Date: 1997 Jul |
Date Detail:
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Created Date: 1997-09-02 Completed Date: 1997-09-02 Revised Date: 2009-10-02 |
Medline Journal Info:
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Nlm Unique ID: 7503323 Medline TA: Br J Clin Pharmacol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 49-56 Citation Subset: IM |
Affiliation:
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Gazi University, Faculty of Pharmacy, Department of Pharmacology, Ankara, Turkey. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid Arteries / drug effects*, physiology, transplantation Benzopyrans / pharmacology* Coronary Artery Bypass Cromakalim Endothelin-1 / pharmacology Female Glyburide / pharmacology Humans Indomethacin / pharmacology Male Mammary Arteries / drug effects*, physiology, transplantation Middle Aged Muscle Contraction / drug effects Muscle Relaxation / drug effects Muscle, Smooth, Vascular / drug effects*, physiology Nitroarginine / pharmacology Norepinephrine / pharmacology Omentum / blood supply Potassium / pharmacology Potassium Channel Blockers Potassium Channels / drug effects* Prostaglandin Endoperoxides, Synthetic / pharmacology Pyrroles / pharmacology* Stomach / blood supply Thromboxane A2 / analogs & derivatives, pharmacology Vasoconstrictor Agents / pharmacology Vasodilator Agents / pharmacology* |
| Chemical | |
Reg. No./Substance:
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0/Benzopyrans; 0/Endothelin-1; 0/Potassium Channel Blockers; 0/Potassium Channels; 0/Prostaglandin Endoperoxides, Synthetic; 0/Pyrroles; 0/Vasoconstrictor Agents; 0/Vasodilator Agents; 10238-21-8/Glyburide; 2149-70-4/Nitroarginine; 51-41-2/Norepinephrine; 53-86-1/Indomethacin; 57576-52-0/Thromboxane A2; 7440-09-7/Potassium; 76898-47-0/15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; 94470-67-4/Cromakalim |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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