Document Detail


The comparison of the responsiveness of human isolated internal mammary and gastroepiploic arteries to levcromakalim: an alternative approach to the management of graft spasm.
MedLine Citation:
PMID:  9241096     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
AIMS: We studied the effectiveness of levcromakalim, a potassium channel opener (KCO), in the prevention and reversal of spasm in arterial grafts used in coronary artery bypass operations, namely, internal mammary artery (IMA) and gastroepiploic artery (GEA). METHODS: Spasm was mimicked in vitro in arterial rings from 109 patients by increasing the vascular tension with noradrenaline, the thromboxane analogue U46619, endothelin-1 and K+. RESULTS: GEA displayed considerably higher contractile force to these agents than IMA. Pretreatment with levcromakalim depressed significantly the maximal contractile responses (either absolute or relative) to noradrenaline and U46619 but did not affect those of endothelin-1 and K+ in both of the arteries. Sensitivities (to all agents, except to endothelin-1) decreased significantly after levcromakalim. In experiments evaluating the antispasmodic activity of levcromakalim, a higher relaxant capacity was observed in GEA than IMA (for K+ contraction; IMA: 31.32 +/- 3.83%, n= 13 vs GEA: 98.01 +/- 0.71%, n=7, P<0.05). This different activity of levcromakalim between two arterial grafts was apparent even when GEA rings were contracted to higher force (g) than that of IMA (for K+ contraction; GEA: 72.56 +/- 4.96%, n = 7). Responses to levcromakalim were similar in IMA and GEA when endothelin-1 was used as the spasmogenic agent (IMA: 80.98 +/- 4.85%, n=10 vs GEA: 91.93 +/- 3.17%, n=7, P>0.05). CONCLUSIONS: Our results provide evidence that levcromakalim may have a therapeutic value in the treatment of spasm of coronary artery bypass grafts, especially GEA.
Authors:
F Akar; B S Uydeş-Dogan; H Tufan; S Aşlamaci; C Köksoy; I Kanzik
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Publication Detail:
Type:  Comparative Study; In Vitro; Journal Article    
Journal Detail:
Title:  British journal of clinical pharmacology     Volume:  44     ISSN:  0306-5251     ISO Abbreviation:  Br J Clin Pharmacol     Publication Date:  1997 Jul 
Date Detail:
Created Date:  1997-09-02     Completed Date:  1997-09-02     Revised Date:  2009-10-02    
Medline Journal Info:
Nlm Unique ID:  7503323     Medline TA:  Br J Clin Pharmacol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  49-56     Citation Subset:  IM    
Affiliation:
Gazi University, Faculty of Pharmacy, Department of Pharmacology, Ankara, Turkey.
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MeSH Terms
Descriptor/Qualifier:
15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid
Arteries / drug effects*,  physiology,  transplantation
Benzopyrans / pharmacology*
Coronary Artery Bypass
Cromakalim
Endothelin-1 / pharmacology
Female
Glyburide / pharmacology
Humans
Indomethacin / pharmacology
Male
Mammary Arteries / drug effects*,  physiology,  transplantation
Middle Aged
Muscle Contraction / drug effects
Muscle Relaxation / drug effects
Muscle, Smooth, Vascular / drug effects*,  physiology
Nitroarginine / pharmacology
Norepinephrine / pharmacology
Omentum / blood supply
Potassium / pharmacology
Potassium Channel Blockers
Potassium Channels / drug effects*
Prostaglandin Endoperoxides, Synthetic / pharmacology
Pyrroles / pharmacology*
Stomach / blood supply
Thromboxane A2 / analogs & derivatives,  pharmacology
Vasoconstrictor Agents / pharmacology
Vasodilator Agents / pharmacology*
Chemical
Reg. No./Substance:
0/Benzopyrans; 0/Endothelin-1; 0/Potassium Channel Blockers; 0/Potassium Channels; 0/Prostaglandin Endoperoxides, Synthetic; 0/Pyrroles; 0/Vasoconstrictor Agents; 0/Vasodilator Agents; 10238-21-8/Glyburide; 2149-70-4/Nitroarginine; 51-41-2/Norepinephrine; 53-86-1/Indomethacin; 57576-52-0/Thromboxane A2; 7440-09-7/Potassium; 76898-47-0/15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; 94470-67-4/Cromakalim

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