Document Detail

A comparison of respiratory function in Afro-Caribbean and Caucasian infants.
MedLine Citation:
PMID:  8143808     Owner:  NLM     Status:  MEDLINE    
Race is recognized as an important determinant of lung function in children and adults, but limited data exist for infants. Accurate interpretation of lung function tests during the neonatal period may depend on appropriate values for predicting normality. The aim of this study was to compare tidal breathing parameters, Hering-Breuer reflex (HBR) activity, and total respiratory compliance (Crs) in healthy newborn caucasian (white) and Afro-Caribbean (black) infants, to determine whether separate reference values were required for these two ethnic groups. Respiratory function was measured in 33 healthy black infants, 18 of whom were premature, and 33 healthy white infants matched for sex, gestational age, weight, postnatal age, and maternal smoking during pregnancy. There were no significant paired differences between black and white infants with respect to minute ventilation, respiratory frequency, the ratio of time to reach peak expiratory flow to total expiratory time, or HBR activity. Values of Crs were similar in black and white full-term infants (37.5 (SD 9.0) versus 35.0 (6.3) ml.kPa-1, respectively) suggesting that, in the immediate newborn period, separate reference values are not necessary for these parameters. However, Crs was somewhat lower in black than white preterm infants (26.0(5.2) versus 29.5(7.2) ml.kPa-1, this difference reaching statistical significance if results were expressed in relation to body weight (95% confidence interval of within-pair differences -4.0 to -0.02 ml.kPa-1 x kg-1; p < 0.05). We conclude that no separate reference values for tidal breathing, Hering-Breuer reflex activity or total respiratory compliance are required for white and black babies in the immediate newborn period.(ABSTRACT TRUNCATED AT 250 WORDS)
J Stocks; M Gappa; P S Rabbette; A F Hoo; Z Mukhtar; K L Costeloe
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The European respiratory journal     Volume:  7     ISSN:  0903-1936     ISO Abbreviation:  Eur. Respir. J.     Publication Date:  1994 Jan 
Date Detail:
Created Date:  1994-04-29     Completed Date:  1994-04-29     Revised Date:  2013-05-23    
Medline Journal Info:
Nlm Unique ID:  8803460     Medline TA:  Eur Respir J     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  11-6     Citation Subset:  IM    
Portex Anaesthesia, Intensive Therapy and Respiratory Medicine Unit, Institute of Child Health, London, UK.
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MeSH Terms
African Continental Ancestry Group*
Caribbean Region / ethnology
European Continental Ancestry Group*
Infant, Newborn / physiology*
Lung Compliance / physiology
Reference Values
Respiration / physiology*
Tidal Volume / physiology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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