Document Detail

A comparison of rectal misoprostol and intravenous oxytocin on hemorrhage and homeostatic changes during cesarean section.
MedLine Citation:
PMID:  23833849     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Post partum bleeding is a major cause of mortality and morbidity in pregnant women. In this study the effects of rectal misoprostol and oxytocin on post-cesarean bleeding are compared.
METHODS: In this clinical trial 100 pregnant women candidate of elective cesarean section (CS) were randomly allocated in one of two groups of patients receiving either 400 micro g of misoprostol, rectally, after spinal anesthesia, or intravenous oxytocin, after delivery of the baby. Intra-operative bleeding, hemoglobin level before and 24 hour after operation, mean arterial blood pressure, heart rate before and after the administration of the drugs, and adverse drug effects.
RESULTS: There was no difference between the groups in age, duration and number of pregnancy, and surgery. The amount of the blood lost in misoprostol group was 578+/-185 cc, and in oxytocin group 620+/-213 cc (p=0.39). Decrease in hemoglobin level in the two groups was not statistically significant (p=0.55). Changes in mean arterial pressure and heart rate were only significant in oxytocin group. Shivering was significantly more common in the misoprostol group and respiratory distress in the oxytocin group. Other adverse effects were equally seen in both groups.
CONCLUSION: Misoprostol is an appropriate alternative for intravenous oxytocin in patients undergoing cesarean section, with lesser side effects and longer duration of action.
Mohammad Reza Fazel; Mansoure-Samimi; Esmaeil-Fakharian
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Publication Detail:
Type:  Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Middle East journal of anaesthesiology     Volume:  22     ISSN:  0544-0440     ISO Abbreviation:  Middle East J Anaesthesiol     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-07-09     Completed Date:  2013-07-23     Revised Date:  2014-10-10    
Medline Journal Info:
Nlm Unique ID:  8604187     Medline TA:  Middle East J Anaesthesiol     Country:  Lebanon    
Other Details:
Languages:  eng     Pagination:  41-6     Citation Subset:  IM    
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MeSH Terms
Administration, Rectal
Blood Pressure / drug effects
Cesarean Section
Heart Rate / drug effects
Hemoglobins / analysis
Infusions, Intravenous
Misoprostol / administration & dosage*,  adverse effects
Oxytocin / administration & dosage*,  adverse effects
Postpartum Hemorrhage / prevention & control*
Reg. No./Substance:
0/Hemoglobins; 0E43V0BB57/Misoprostol; 50-56-6/Oxytocin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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