| A comparison of protective effects between L-histidine and hypothermia against ischemia-induced neuronal damage in gerbil hippocampus. | |
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MedLine Citation:
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PMID: 16914139 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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An increase in the histamine concentration in the brain has been demonstrated to provide protective effects against ischemia/reperfusion brain injury. Since hypothermia and barbiturates are also regarded to protect ischemic brains, effects of postischemic treatments were compared in gerbils between mild hypothermia and intraperitoneal administration of L-histidine, a precursor of histamine. Furthermore, effects of thioperamide, a histamine H(3) receptor antagonist, were evaluated in histidine-treated gerbils after 60 days. Transient forebrain ischemia for 4 min at 37 degrees C provoked severe neuronal damage in the hippocampal CA1 pyramidal cells after 7 days. Postischemic hypothermia (33 degrees C) for 3 h under pentobarbital anesthesia alleviated neuronal death, and the number of preserved neurons was 77+/-56/mm (mean+/-S.D., n=14). The effect of L-histidine injected three times, immediately, 6 h, and 24 h after reperfusion (1,000 mg/kg, i.p., each), was more prominent than that of hypothermia, and the number of preserved neurons was 142+/-55/mm (n=14). When the histologic outcome was evaluated after 60 days, most neurons were damaged in both the hypothermic and histidine groups. The improvement of the histologic outcome was observed even after 60 days in animals injected with thioperamide, immediately and 6 h after reperfusion (5 mg/kg, s.c., each), with three injections of l-histidine. The number of preserved neurons was 133+/-88/mm (n=10), while that in the hypothermic group was 7+/-15 (n=10). Activation of the central histaminergic system provides beneficial effects against cerebral ischemia. |
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Authors:
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Naoto Adachi; Keyue Liu; Atsuko Motoki; Norihito Hiraga; Yumi Irisawa; Kazunori Semba; Tatsuru Arai |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't Date: 2006-07-25 |
Journal Detail:
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Title: European journal of pharmacology Volume: 546 ISSN: 0014-2999 ISO Abbreviation: Eur. J. Pharmacol. Publication Date: 2006 Sep |
Date Detail:
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Created Date: 2006-09-11 Completed Date: 2007-01-11 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 1254354 Medline TA: Eur J Pharmacol Country: Netherlands |
Other Details:
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Languages: eng Pagination: 69-73 Citation Subset: IM |
Affiliation:
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Department of Anesthesiology and Resuscitology, Ehime University Graduate School of Medicine, Shitsukawa, Touon-shi, Ehime 791-0295, Japan. nadachi@m.ehime-u.ac.jp |
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Brain Ischemia / pathology, therapy* Drug Therapy, Combination Gerbillinae Hippocampus / drug effects*, pathology Histamine / pharmacology Histamine Antagonists / pharmacology Histidine / pharmacology*, therapeutic use Hypnotics and Sedatives / administration & dosage Hypothermia, Induced* Male Neuroprotective Agents / pharmacology*, therapeutic use Pentobarbital / administration & dosage Piperidines / pharmacology Prosencephalon / blood supply* Pyramidal Cells / drug effects*, pathology Reperfusion Injury / pathology, prevention & control* Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Histamine Antagonists; 0/Hypnotics and Sedatives; 0/Neuroprotective Agents; 0/Piperidines; 106243-16-7/thioperamide; 51-45-6/Histamine; 71-00-1/Histidine; 76-74-4/Pentobarbital |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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