Document Detail

A comparison of prophylactic ondansetron and metoclopramide administration in patients undergoing major neurosurgical procedures.
MedLine Citation:
PMID:  9038459     Owner:  NLM     Status:  MEDLINE    
In a prospective, randomised, double-blind trial, we assessed the relative efficacy of prophylactic ondansetron and metoclopramide administration in the reduction of postoperative nausea and vomiting in 60 patients undergoing routine major neurosurgical procedures. The patients were randomly allocated into one of two groups. Both groups received a standardised anaesthetic. When the dura mater was closed, patients in group A received an intravenous injection of metoclopramide 10 mg whilst group B received ondansetron 8 mg intravenously. Patients who received metoclopramide experienced less postoperative nausea and vomiting than those who received ondansetron in the 48 h following surgery (17 (56%) versus 9 (30%) p = 0.038). In the light of these findings, we believe that ondansetron is an inappropriate agent for the prevention of postoperative nausea and vomiting in the neurosurgical population.
S C Pugh; N C Jones; L Z Barsoum
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Anaesthesia     Volume:  51     ISSN:  0003-2409     ISO Abbreviation:  Anaesthesia     Publication Date:  1996 Dec 
Date Detail:
Created Date:  1997-03-07     Completed Date:  1997-03-07     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370524     Medline TA:  Anaesthesia     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1162-4     Citation Subset:  AIM; IM    
Department of Anaesthetics, University Hospital of Wales, Heath Park, Cardiff.
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MeSH Terms
Antiemetics / therapeutic use*
Double-Blind Method
Metoclopramide / therapeutic use
Middle Aged
Nausea / prevention & control*
Ondansetron / therapeutic use
Postoperative Complications / prevention & control*
Prospective Studies
Vomiting / prevention & control*
Reg. No./Substance:
0/Antiemetics; 364-62-5/Metoclopramide; 99614-02-5/Ondansetron

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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