| A comparison of prophylactic ondansetron and metoclopramide administration in patients undergoing major neurosurgical procedures. | |
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MedLine Citation:
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PMID: 9038459 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In a prospective, randomised, double-blind trial, we assessed the relative efficacy of prophylactic ondansetron and metoclopramide administration in the reduction of postoperative nausea and vomiting in 60 patients undergoing routine major neurosurgical procedures. The patients were randomly allocated into one of two groups. Both groups received a standardised anaesthetic. When the dura mater was closed, patients in group A received an intravenous injection of metoclopramide 10 mg whilst group B received ondansetron 8 mg intravenously. Patients who received metoclopramide experienced less postoperative nausea and vomiting than those who received ondansetron in the 48 h following surgery (17 (56%) versus 9 (30%) p = 0.038). In the light of these findings, we believe that ondansetron is an inappropriate agent for the prevention of postoperative nausea and vomiting in the neurosurgical population. |
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Authors:
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S C Pugh; N C Jones; L Z Barsoum |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: Anaesthesia Volume: 51 ISSN: 0003-2409 ISO Abbreviation: Anaesthesia Publication Date: 1996 Dec |
Date Detail:
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Created Date: 1997-03-07 Completed Date: 1997-03-07 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0370524 Medline TA: Anaesthesia Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 1162-4 Citation Subset: AIM; IM |
Affiliation:
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Department of Anaesthetics, University Hospital of Wales, Heath Park, Cardiff. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Antiemetics
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therapeutic use* Double-Blind Method Female Humans Male Metoclopramide / therapeutic use Middle Aged Nausea / prevention & control* Neurosurgery* Ondansetron / therapeutic use Postoperative Complications / prevention & control* Prospective Studies Vomiting / prevention & control* |
| Chemical | |
Reg. No./Substance:
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0/Antiemetics; 364-62-5/Metoclopramide; 99614-02-5/Ondansetron |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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