Document Detail


A comparison of the pregnancy-terminating potencies of three anti-progestins in guinea-pigs, and the effects of sulprostone.
MedLine Citation:
PMID:  8066099     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The anti-progestins mifepristone, lilopristone (ZK 98734) and HRP 2000 were equipotent at terminating the pregnancy of guinea-pigs during mid-gestation, although mifepristone was more effective at low doses. Sulprostone administration on the day following anti-progestin treatment tended to increase the effectiveness of mifepristone and HRP 2000, without affecting the time interval between the start of the anti-progestin treatment and the day of abortion. It is concluded that, of the three afferent anti-progestins used, none is more potent than the other two at terminating pregnancy in the animal model used. The co-administration of a prostaglandin E2 (PGE2) analogue tends to increase the effectiveness of the anti-progestin.
Authors:
N L Poyser; M L Forcelledo
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Prostaglandins, leukotrienes, and essential fatty acids     Volume:  50     ISSN:  0952-3278     ISO Abbreviation:  Prostaglandins Leukot. Essent. Fatty Acids     Publication Date:  1994 May 
Date Detail:
Created Date:  1994-09-19     Completed Date:  1994-09-19     Revised Date:  2010-02-04    
Medline Journal Info:
Nlm Unique ID:  8802730     Medline TA:  Prostaglandins Leukot Essent Fatty Acids     Country:  SCOTLAND    
Other Details:
Languages:  eng     Pagination:  245-7     Citation Subset:  IM    
Affiliation:
Department of Pharmacology, University of Edinburgh Medical School, Scotland, UK.
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MeSH Terms
Descriptor/Qualifier:
Abortifacient Agents* / administration & dosage
Abortifacient Agents, Steroidal / administration & dosage
Abortion, Induced / methods*
Animals
Dinoprostone / administration & dosage,  analogs & derivatives
Drug Evaluation, Preclinical
Drug Synergism
Estrenes / administration & dosage
Female
Guinea Pigs
Mifepristone / administration & dosage
Norpregnadienes
Pregnancy
Pregnenediones / administration & dosage
Progestins / antagonists & inhibitors*
Chemical
Reg. No./Substance:
0/Abortifacient Agents; 0/Abortifacient Agents, Steroidal; 0/Estrenes; 0/Norpregnadienes; 0/Pregnenediones; 0/Progestins; 0/ulipristal; 363-24-6/Dinoprostone; 60325-46-4/sulprostone; 84371-65-3/Mifepristone; 97747-88-1/lilopristone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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