Document Detail


A comparison of oxitropium bromide and ipratropium bromide in asthma.
MedLine Citation:
PMID:  6230249     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Oxitropium bromide is a derivative of scopolamine and is an anticholinergic drug. Twenty asthmatics completed the study in which they received, in randomised double-blind fashion, placebo, ipratropium bromide 80 micrograms, and oxitropium bromide 200 micrograms. The patients recorded peak expiratory flow immediately before inhalation and up to 10 h afterwards. PEF were significantly higher than placebo between 10 min and 10 h, for both active treatments. There were no significant differences between values on oxitropium bromide and ipratropium bromide at any time points. Side effects were minimal and oxitropium bromide is an effective bronchodilator in asthma.
Authors:
E T Peel; G Anderson; B Cheong; N Broderick
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article    
Journal Detail:
Title:  European journal of respiratory diseases     Volume:  65     ISSN:  0106-4339     ISO Abbreviation:  Eur J Respir Dis     Publication Date:  1984 Feb 
Date Detail:
Created Date:  1984-04-12     Completed Date:  1984-04-12     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8006891     Medline TA:  Eur J Respir Dis     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  106-8     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Aerosols
Aged
Asthma / drug therapy*,  physiopathology
Atropine Derivatives / therapeutic use*
Clinical Trials as Topic
Double-Blind Method
Female
Humans
Ipratropium / administration & dosage,  therapeutic use*
Male
Middle Aged
Peak Expiratory Flow Rate
Random Allocation
Scopolamine Derivatives / administration & dosage,  therapeutic use*
Time Factors
Chemical
Reg. No./Substance:
0/Aerosols; 0/Atropine Derivatives; 0/Scopolamine Derivatives; 30286-75-0/oxitropium; 60205-81-4/Ipratropium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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