| A comparison of omeprazole and ranitidine in the prevention of recurrence of benign esophageal stricture. Restore Investigator Group. | |
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MedLine Citation:
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PMID: 7926495 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND/AIMS: Dilatation combined with subsequent pharmacological control of gastroesophageal reflux represents a logical but poorly documented approach to the management of benign esophageal stricture. This large trial (366 patients) aimed to assess whether omeprazole as the most effective available medication for gastroesophageal reflux disease prevents recurrent stricture formation. METHODS: Patients (n = 366) were randomized in a double-blind study to undergo either omeprazole (20 mg once daily; 180 evaluable patients) or ranitidine therapy (150 mg twice daily; 185 evaluable patients) for 1 year after dilatation to 12-18-mm diameter (36-54F gauge). Subsequently, endoscopy and dilatation were performed when clinically indicated and endoscopy on completion. Symptoms were assessed at clinic visits every 3 months and using weekly diary cards. RESULTS: Fewer patients undergoing omeprazole therapy required redilatation compared with those on ranitidine (43 of 143 [30%] vs. 66 of 143 [46%] by 12 months; P < 0.01), and patients in the omeprazole group needed fewer redilatations during the year (0.48 vs. 1.08; P < 0.01). On completion, symptom relief favored omeprazole: 76% of patients in the omeprazole group were free of dysphagia (compared with 64% in the ranitidine group; P < 0.05); 83% were able to accept a normal diet (69%; P < 0.01); and 65% were completely asymptomatic (43%; P < 0.001). CONCLUSIONS: Omeprazole, 20 mg once daily, was more effective than ranitidine, 150 mg twice daily, as prophylaxis against stricture recurrence and in providing symptom relief. |
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Authors:
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P M Smith; G D Kerr; R Cockel; B A Ross; C M Bate; P Brown; M W Dronfield; J R Green; W S Hislop; A Theodossi |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article; Multicenter Study; Randomized Controlled Trial |
Journal Detail:
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Title: Gastroenterology Volume: 107 ISSN: 0016-5085 ISO Abbreviation: Gastroenterology Publication Date: 1994 Nov |
Date Detail:
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Created Date: 1994-11-22 Completed Date: 1994-11-22 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0374630 Medline TA: Gastroenterology Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1312-8 Citation Subset: AIM; IM |
Affiliation:
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Llandough Hospital, Penarth, South Glamorgan, Wales. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Chi-Square Distribution Dilatation Double-Blind Method Esophageal Stenosis / drug therapy, prevention & control*, therapy Esophagoscopy Female Great Britain Humans Logistic Models Male Middle Aged Omeprazole / administration & dosage, therapeutic use* Ranitidine / administration & dosage, therapeutic use* Recurrence |
| Chemical | |
Reg. No./Substance:
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66357-35-5/Ranitidine; 73590-58-6/Omeprazole |
| Comments/Corrections | |
Comment In:
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Gastroenterology. 1994 Nov;107(5):1545-8
[PMID:
7926519
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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