Document Detail

A comparison of a new slow release aspirin ("slow aspirin") with plain aspirin in the treatment of rheumatoid disease.
MedLine Citation:
PMID:  881098     Owner:  NLM     Status:  MEDLINE    
In a single centre double-blind crossover study in eighteen patients with established rheumatoid disease, a new slow release aspirin ("slow aspirin") was compared with plain aspirin with respect to patient tolerability and gastric mucosal damage as observed at gastroscopy. "Slow aspirin" was significantly better than plain aspirin with regard to gastroscopic findings. With "slow aspirin", the gastric mucosal appearances were definitely better in eight patients, worse in two, and eight showed no difference. There was a high incidence of gastric ulceration or erosions in the groups as a whole (39%) but few patients complained of dyspepsia. There was little difference in the ability of both plain and "slow aspirin" in controlling the patients' joint symptoms. Evidence has been provided to suggest that "slow aspirin" is less injurious to the gastric mucosa. In an attempt to reduce gastric mucosal damage due to prolonged aspirin treatment it is therefore concluded that "slow aspirin" merits consideration in the management of chronic rheumatoid disease.
D N Clarke; N A Mowat; P W Brunt; L S Bain
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Controlled Clinical Trial; Journal Article    
Journal Detail:
Title:  The Journal of international medical research     Volume:  5     ISSN:  0300-0605     ISO Abbreviation:  J. Int. Med. Res.     Publication Date:  1977  
Date Detail:
Created Date:  1977-09-17     Completed Date:  1977-09-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0346411     Medline TA:  J Int Med Res     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  270-5     Citation Subset:  IM    
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MeSH Terms
Arthritis, Rheumatoid / drug therapy*
Aspirin / administration & dosage*,  adverse effects,  therapeutic use
Delayed-Action Preparations
Double-Blind Method
Drug Tolerance
Dyspepsia / chemically induced
Gastric Mucosa / drug effects,  pathology
Middle Aged
Stomach Ulcer / chemically induced,  pathology
Reg. No./Substance:
0/Delayed-Action Preparations; 50-78-2/Aspirin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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