Document Detail

A comparison of a new skin closure device and intradermal sutures in the closure of full-thickness surgical incisions.
MedLine Citation:
PMID:  23018695     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: A novel topical skin adhesive system was developed to close the outermost layer of skin in an expeditious manner. To determine its clinical utility, a clinical investigation was undertaken to demonstrate equivalence of a new adhesive skin closure system (Prineo Skin Closure System) to intradermal sutures in wound closure.
METHODS: The investigation included 83 patients who underwent elective abdominoplasty, circumferential body lift procedures, and breast reconstruction with deep inferior epigastric perforator flaps. Incisions were divided in half, and each half was randomized to wound closure with the new skin closure system, including a pressure-sensitive adhesive mesh tape for wound edge approximation and next-generation cyanoacrylate or intradermal sutures. Postoperative evaluations took place at 24 hours, 7 days, 12 to 25 days, 90 days, 6 months, and 12 months.
RESULTS: The new skin closure system was found to be equivalent to intradermal sutures for the continuous approximation of wounds. The upper limit of the two-sided 90 percent confidence interval for difference in proportions was 10.9 percent. The mean time to closure for the new skin closure system was 1.46 minutes, approximately 5 minutes faster than that for intradermal sutures (p < 0.0001). Both treatments had similar incision healing and cosmetic outcomes. No quantitative or qualitative differences of clinical significance were evident between the treatment groups.
CONCLUSIONS: The Prineo Skin Closure System can be considered equivalent to intradermal sutures for full-thickness surgical incisions with regard to safety and effectiveness. The ease and speed of application contribute to shortened operative times (4.5 times faster than intradermal sutures).
Dirk Richter; Alexander Stoff; Venkat Ramakrishnan; Klaus Exner; Jan Jernbeck; Phillip N Blondeel
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Publication Detail:
Type:  Comparative Study; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Plastic and reconstructive surgery     Volume:  130     ISSN:  1529-4242     ISO Abbreviation:  Plast. Reconstr. Surg.     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-09-28     Completed Date:  2012-12-14     Revised Date:  2014-10-13    
Medline Journal Info:
Nlm Unique ID:  1306050     Medline TA:  Plast Reconstr Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  843-50     Citation Subset:  AIM; IM    
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MeSH Terms
Abdominoplasty / methods
Cyanoacrylates / therapeutic use
Dermis / surgery*
Equipment Design
Equipment Safety
Mammaplasty / methods
Middle Aged
Prospective Studies
Reconstructive Surgical Procedures / adverse effects,  methods*
Safety Management
Suture Techniques / instrumentation
Tissue Adhesives / therapeutic use
Wound Closure Techniques / instrumentation*
Wound Healing / physiology*
Reg. No./Substance:
0/Cyanoacrylates; 0/Tissue Adhesives

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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