Document Detail

A comparison of methods for assessing total arterial compliance.
MedLine Citation:
PMID:  20090775     Owner:  NLM     Status:  MEDLINE    
There are several methods of assessing total arterial compliance (TAC) based on the two element Windkessel model, which is a ratio of pressure and volume, but the optimal technique is unclear. In this study, three methods of estimating TAC were compared to determine which was the most robust in a large group of patients with and without cardiovascular risk. In all, 320 patients (170 men; age 55+/-10) were studied; TAC was determined by the pulse-pressure method (PPM), the area method (AM) and the stroke volume/pulse-pressure method (SVPP). We obtained arterial waveforms using radial applanation tonometry, dimensions using two-dimensional echocardiography and flow data by Doppler. Clinical data, risk factors, echo parameters and TAC by all three methods were then compared. TAC (ml mm Hg(-1)) by the PPM was 1.24+/-0.51, by the AM 1.84+/-0.90 and by the SVPP 1.96+/-0.76 (P<0.0001 between groups). Correlation was good between all methods: PPM/AM r=0.83, PPM/SVPP r=0.94 and AM/SVPP r=0.80 (all P<0.0001). Subgroup analysis showed significant differences between patients with and those without cardiovascular risk for all three methods; TAC-AM and TAC-SVPP values were similar and significantly higher than TAC-PPM. The only significant relationships observed with TAC and echo parameters were in left ventricular (LV) septal thickness (R(2)=0.07; P<0.0001) and LV mass (R(2)=0.04; P=0.004). Normal and abnormal values of TAC vary according to method, which should be expressed. Each of the techniques shows good correlation with each other, however, values for TAC-PPM are significantly lower. TAC-PPM and TAC-SVPP are comparable in determining differences between groups with and without cardiovascular risk.
B A Haluska; L Jeffriess; J Brown; S Carlier; T H Marwick
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Publication Detail:
Type:  Comparative Study; Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-01-21
Journal Detail:
Title:  Journal of human hypertension     Volume:  24     ISSN:  1476-5527     ISO Abbreviation:  J Hum Hypertens     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-03-18     Completed Date:  2010-06-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8811625     Medline TA:  J Hum Hypertens     Country:  England    
Other Details:
Languages:  eng     Pagination:  254-62     Citation Subset:  IM    
University of Queensland School of Medicine, Brisbane, Queensland,Australia.
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MeSH Terms
Blood Pressure / physiology
Brachial Artery / physiology,  ultrasonography
Compliance / physiology*
Cross-Sectional Studies
Hemodynamics / physiology
Hypertension / epidemiology,  physiopathology*,  ultrasonography*
Hypertrophy, Left Ventricular / epidemiology,  physiopathology,  ultrasonography
Linear Models
Middle Aged
Models, Cardiovascular*
Risk Factors
Stroke Volume / physiology
Ventricular Function, Left
Comment In:
J Hum Hypertens. 2010 Apr;24(4):227-9   [PMID:  20016522 ]

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