| A comparison of the metabolism of eighteen-carbon 13C-unsaturated fatty acids in healthy women. | |
| | |
MedLine Citation:
|
PMID: 14679164 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Altered use of different dietary fatty acids may contribute to several chronic diseases, including obesity, noninsulin-dependent diabetes mellitus, and cardiovascular disease. However, few comparative data are available to support this link, so the goal of the present study was to compare the metabolism of [(13)C]oleate, [(13)C]alpha-linolenate, [(13)C]elaidate, and [(13)C]linoleate through oxidation and incorporation into plasma lipid fractions and adipose tissue. Each tracer was given as a single oral bolus to six healthy women. Samples were collected over 8 days, and (13)C was analyzed using isotope ratio mass spectrometry. At 9 h postdose, cumulative oxidation was similar for [(13)C]elaidate, [(13)C]oleate, and [(13)C]alpha-linolenate (19 +/- 1%, 20 +/- 4%, and 19 +/- 3% dose, respectively). Significantly lower oxidation of [(13)C]linoleate (12 +/- 4% dose; P < 0.05) was accompanied by its higher incorporation into plasma phospholipids and cholesteryl esters. Abdominal adipose tissue was enriched with [(13)C]alpha-linolenate, [(13)C]elaidate, or [(13)C]linoleate within 6 h. The percentage linoleate in plasma phospholipids correlated positively with [(13)C]linoleate and [(13)C]elaidate oxidation, indicating a potential role of background diet. Conversion of [(13)C]linoleate and [(13)C]alpha-linolenate to longer chain polyunsaturates was a quantitatively minor route of utilization. |
| | |
Authors:
|
U McCloy; M A Ryan; P B Pencharz; R J Ross; S C Cunnane |
Related Documents
:
|
17740584 - Inheritance of linoleic and oleic acids in maize. 12172844 - Metabolic profiling of oxylipins in germinating cucumber seedlings--lipoxygenase-depend... 8143994 - Biochemical epidemiology of colon cancer: effect of types of dietary fiber on colonic d... 1173274 - Distribution of fatty acids during germination of cottonseeds. 3269714 - A simple method for determination of plasma thiocyanate. 17497884 - Evaluation of fatty acid extraction methods for thraustochytrium sp. onc-t18. |
Publication Detail:
|
Type: Clinical Trial; Comparative Study; Journal Article; Research Support, Non-U.S. Gov't Date: 2003-12-16 |
Journal Detail:
|
Title: Journal of lipid research Volume: 45 ISSN: 0022-2275 ISO Abbreviation: J. Lipid Res. Publication Date: 2004 Mar |
Date Detail:
|
Created Date: 2004-03-04 Completed Date: 2004-11-10 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0376606 Medline TA: J Lipid Res Country: United States |
Other Details:
|
Languages: eng Pagination: 474-85 Citation Subset: IM |
Affiliation:
|
Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada M5S 3E2. ursula.mccoy@utoronto.ca |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adipose Tissue
/
metabolism Administration, Oral Adult Breath Tests Carbon Isotopes Fatty Acids, Unsaturated / administration & dosage, blood, chemistry*, metabolism* Female Health Humans Oxidation-Reduction Time Factors |
| Chemical | |
Reg. No./Substance:
|
0/Carbon Isotopes; 0/Fatty Acids, Unsaturated |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Lipid transfer particle mediates the delivery of diacylglycerol from lipophorin to fat body in larva...
Next Document: Genome-wide linkage scan reveals multiple susceptibility loci influencing lipid and lipoprotein leve...