| A comparison of medetomidine-propofol and medetomidine-midazolam-propofol anesthesia in rabbits. | |
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MedLine Citation:
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PMID: 1460852 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We evaluated and compared the effects of medetomidine-propofol and medetomidine-midazolam-propofol anesthesia in rabbits. Fourteen New Zealand White rabbits were randomly assigned to receive either medetomidine (0.25 mg/kg, i.m.)-atropine (0.5 mg/kg, i.m.)-propofol (4 mg/kg, i.v.) (n = 7) or medetomidine (0.25 mg/kg, i.m.)-atropine (0.5 mg/kg, i.m.)-midazolam (0.5 mg/kg, i.m.)-propofol (2 mg/kg, i.v.) (n = 7). Five minutes after medetomidine-atropine or medetomidine-atropine-midazolam i.m. injection, propofol was administered i.v. Both medetomidine and medetomidine-midazolam rapidly (within 5 minutes) immobilized all rabbits and greatly eased the i.v. administration of propofol. Endotracheal intubation was accomplished easily after propofol injection in both groups. There was no significant difference between medetomidine-propofol and medetomidine-midazolam-propofol-treated rabbits in heart rate, respiratory rate, mean arterial pressure, or end-tidal CO2. The addition of midazolam to the medetomidine-propofol regimen significantly (P < 0.05) prolonged the duration of ear-pinch analgesia (25.0 +/- 7.1 vs. 36.7 +/- 8.9 minutes), the time from extubation to sternal recumbency (0.0 vs. 26.7 +/- 8.1 minutes), and the time from extubation to standing (0.0 vs. 39.5 +/- 11.3 minutes) without inducing significant changes in arterial blood pressure and end-tidal alveolar CO2. We consider both medetomidine-propofol and medetomidine-midazolam-propofol combinations to be safe and effective regimens for induction and short-term anesthesia in rabbits. |
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Authors:
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J C Ko; J C Thurmon; W J Tranquilli; G J Benson; W A Olson |
Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Laboratory animal science Volume: 42 ISSN: 0023-6764 ISO Abbreviation: Lab. Anim. Sci. Publication Date: 1992 Oct |
Date Detail:
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Created Date: 1993-01-14 Completed Date: 1993-01-14 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 1266503 Medline TA: Lab Anim Sci Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 503-7 Citation Subset: IM |
Affiliation:
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Dept. of Small Animal Clinical Sciences, Virginia-Maryland Regional College of Veterinary Medicine, Blacksburg 24061-0442. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anesthesia, General
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veterinary* Animals Drug Combinations Imidazoles / administration & dosage* Injections, Intramuscular / veterinary Injections, Intravenous / veterinary Medetomidine Midazolam / administration & dosage* Propofol / administration & dosage* Rabbits* Random Allocation |
| Chemical | |
Reg. No./Substance:
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0/Drug Combinations; 0/Imidazoles; 2078-54-8/Propofol; 59467-70-8/Midazolam; 86347-14-0/Medetomidine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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