| A comparison of maximal inspiratory pressure and forced vital capacity as potential criteria for initiating non-invasive ventilation in amyotrophic lateral sclerosis. | |
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MedLine Citation:
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PMID: 17453639 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Using a retrospective analysis of 161 patients with amyotrophic lateral sclerosis (ALS) from the Western ALS study group (WALS) database, the sensitivity of maximal inspiratory pressure (MIP)< -60 cm H(2)O and forced vital capacity (FVC)< 50% as US Medicare thresholds for initiating non-invasive ventilation (NIV) were compared. Sixty-five per cent of patients at enrollment met the MIP criterion, compared with only 8% of patients who met the FVC criterion. There were no cases in which FVC< 50% antedated MIP< -60 cm H(2)O. The longitudinal data showed that patients reached the MIP criterion 4 to 6.5 months earlier than the FVC criterion. For patients with clinical signs and symptoms needing treatment with NIV, a MIP< -60 cm H(2)O allows US clinicians to obtain non-invasive ventilatory support for patients earlier than if using the FVC criterion alone. |
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Authors:
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Michelle Mendoza; Deborah F Gelinas; Dan H Moore; Robert G Miller |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Amyotrophic lateral sclerosis : official publication of the World Federation of Neurology Research Group on Motor Neuron Diseases Volume: 8 ISSN: 1748-2968 ISO Abbreviation: Amyotroph Lateral Scler Publication Date: 2007 Apr |
Date Detail:
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Created Date: 2007-04-24 Completed Date: 2007-06-07 Revised Date: 2009-11-17 |
Medline Journal Info:
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Nlm Unique ID: 101283386 Medline TA: Amyotroph Lateral Scler Country: England |
Other Details:
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Languages: eng Pagination: 106-11 Citation Subset: IM |
Affiliation:
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Forbes Norris MDA/ALS Research Center, San Francisco, CA 94115, USA. mendozmc@cpmcri.org |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Amyotrophic Lateral Sclerosis / diagnosis*, therapy* Female Humans Inspiratory Capacity* Male Maximal Voluntary Ventilation Middle Aged Patient Selection* Prognosis Reproducibility of Results Respiration, Artificial / methods* Retrospective Studies Sensitivity and Specificity Vital Capacity* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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