Document Detail

A comparison of maximal inspiratory pressure and forced vital capacity as potential criteria for initiating non-invasive ventilation in amyotrophic lateral sclerosis.
MedLine Citation:
PMID:  17453639     Owner:  NLM     Status:  MEDLINE    
Using a retrospective analysis of 161 patients with amyotrophic lateral sclerosis (ALS) from the Western ALS study group (WALS) database, the sensitivity of maximal inspiratory pressure (MIP)< -60 cm H(2)O and forced vital capacity (FVC)< 50% as US Medicare thresholds for initiating non-invasive ventilation (NIV) were compared. Sixty-five per cent of patients at enrollment met the MIP criterion, compared with only 8% of patients who met the FVC criterion. There were no cases in which FVC< 50% antedated MIP< -60 cm H(2)O. The longitudinal data showed that patients reached the MIP criterion 4 to 6.5 months earlier than the FVC criterion. For patients with clinical signs and symptoms needing treatment with NIV, a MIP< -60 cm H(2)O allows US clinicians to obtain non-invasive ventilatory support for patients earlier than if using the FVC criterion alone.
Michelle Mendoza; Deborah F Gelinas; Dan H Moore; Robert G Miller
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Amyotrophic lateral sclerosis : official publication of the World Federation of Neurology Research Group on Motor Neuron Diseases     Volume:  8     ISSN:  1748-2968     ISO Abbreviation:  Amyotroph Lateral Scler     Publication Date:  2007 Apr 
Date Detail:
Created Date:  2007-04-24     Completed Date:  2007-06-07     Revised Date:  2009-11-17    
Medline Journal Info:
Nlm Unique ID:  101283386     Medline TA:  Amyotroph Lateral Scler     Country:  England    
Other Details:
Languages:  eng     Pagination:  106-11     Citation Subset:  IM    
Forbes Norris MDA/ALS Research Center, San Francisco, CA 94115, USA.
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MeSH Terms
Aged, 80 and over
Amyotrophic Lateral Sclerosis / diagnosis*,  therapy*
Inspiratory Capacity*
Maximal Voluntary Ventilation
Middle Aged
Patient Selection*
Reproducibility of Results
Respiration, Artificial / methods*
Retrospective Studies
Sensitivity and Specificity
Vital Capacity*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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