| A comparison of major histocompatibility complex SNPs in Han Chinese residing in Taiwan and Caucasians. | |
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MedLine Citation:
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PMID: 16544196 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Genetic dissection of complex diseases is both important and challenging. The human major histocompatibility complex is involved in many human diseases and genetic mechanisms. This highly polymorphic chromosome region has been extensively studied in Caucasians but not as well in Asians. Thus, we compared genotypic distributions, linkage disequilibria and haplotype blocks between Caucasian and Taiwan's Han Chinese populations. Moreover, we investigated the population admixture and phylogenetic system in Han Chinese residing in Taiwan. The results show that Taiwan's Han Chinese differ drastically in genotypic information compared with Caucasians but are relatively homogeneous among the three major ethnic subgroups, Minnan, Hakka and Mainlanders. Differences in allele frequency (AF) between Taiwanese and Caucasians in some disease-associated loci may reveal clues to differences in disease prevalence. The results of ethnic heterogeneity imply that public databases should be used with caution in cases where the study population(s) differs from the population characterized in the database. The high homogeneity we observed among the Taiwanese subpopulations mitigates the possibility of spurious association caused by ignoring population stratification in Taiwanese disease gene association studies. These results are useful for understanding our genetic background and designing future disease gene mapping studies. |
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Authors:
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Hsin-Chou Yang; Chien-Hsin Lin; Chia-Ling Hsu; Shuen-Iu Hung; Jer-Yuan Wu; Wen-Harn Pan; Yuan-Tsong Chen; Cathy S J Fann |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't Date: 2006-03-17 |
Journal Detail:
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Title: Journal of biomedical science Volume: 13 ISSN: 1021-7770 ISO Abbreviation: J. Biomed. Sci. Publication Date: 2006 Jul |
Date Detail:
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Created Date: 2006-07-05 Completed Date: 2006-10-24 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9421567 Medline TA: J Biomed Sci Country: Netherlands |
Other Details:
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Languages: eng Pagination: 489-98 Citation Subset: IM |
Affiliation:
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Academia Sinica, Institute of Biomedical Sciences, 128 Academia Road, Section 2 Nankang, Taipei 115, Taiwan, ROC. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Asian Continental Ancestry Group
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genetics* Ethnic Groups / genetics* European Continental Ancestry Group / genetics* Gene Frequency Genetics, Population* Genotype Haplotypes / genetics Humans Linkage Disequilibrium Major Histocompatibility Complex / genetics* Models, Genetic Phylogeny Polymorphism, Genetic* Polymorphism, Single Nucleotide / genetics* Taiwan |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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