| A comparison of the maintenance and recovery charcateristic of sevoflurane-nitrous oxide against isoflurane-nitrous oxide anaesthesia. | |
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MedLine Citation:
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PMID: 11284610 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: To compare the maintenance and recovery characteristics of sevoflurane and isoflurane anaesthesia in Malaysian patients. METHOD: This is a prospective, open labelled, randomized, controlled study. Sixty unpremedicated ASA I or II patients (aged 18-50 years), scheduled for elective breast lump excision were randomly allocated to receive either isoflurane or sevoflurane for the maintenance of anaesthesia following fentanyl and propofol intravenous induction. The systolic, diastolic, mean arterial blood pressure and heart rate were measured. The speed of recovery was measured by time to eye opening, time to following simple command, and time to correctly giving own names and address. The incidence of postoperative complication was also recorded. RESULTS: The trend of systolic blood pressure was significantly higher in the isoflurane group as compared to the sevoflurane group for the duration of anaesthesia (p < 0.001, by ANOVA for repeated measurement) but the trend of heart rate was similar for both groups. The recovery time was faster in the isoflurane group. [mean time of eye opening (SD) = 6.8 (2.2) vs 10.7 (4.4) min, p < 0.001; mean time of sticking tongue out (SD) = 7.9 (2.9) vs 11.5 (4.7) min, p < 0.01; mean time of giving own name (SD) = 7.8 (2.7) vs 11.8 (4.8) min, p < 0.001, mean time of giving own address (SD) = 8.4 (2.9) vs 12.0 (4.7) min, p < 0.01]. No major adverse effects were encountered postoperatively and the incidences of minor adverse effects were low in both groups. CONCLUSION: We concluded that sevoflurane is a safe alternative to isoflurane but in these short procedures, awakening time was surprisingly slower than after isoflurane. |
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Authors:
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C L Chiu; Y K Chan; G S Ong; A E Delilkan |
Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: Singapore medical journal Volume: 41 ISSN: 0037-5675 ISO Abbreviation: Singapore Med J Publication Date: 2000 Nov |
Date Detail:
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Created Date: 2001-04-03 Completed Date: 2001-04-26 Revised Date: 2009-11-03 |
Medline Journal Info:
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Nlm Unique ID: 0404516 Medline TA: Singapore Med J Country: Singapore |
Other Details:
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Languages: eng Pagination: 530-3 Citation Subset: IM |
Affiliation:
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Department of Anaesthesia, University of Malaya Medical Centre, Kuala Lumpur, Malaysia. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Anesthesia Recovery Period* Anesthetics, Inhalation / pharmacology, therapeutic use* Blood Pressure / drug effects Drug Therapy, Combination Female Heart Rate / drug effects Humans Isoflurane / pharmacology, therapeutic use* Malaysia Mastectomy, Segmental Methyl Ethers / pharmacology, therapeutic use* Middle Aged Monitoring, Intraoperative Nitrous Oxide / pharmacology, therapeutic use* Prospective Studies Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Anesthetics, Inhalation; 0/Methyl Ethers; 10024-97-2/Nitrous Oxide; 26675-46-7/Isoflurane; 28523-86-6/sevoflurane |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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