Document Detail

A comparison of the maintenance and recovery charcateristic of sevoflurane-nitrous oxide against isoflurane-nitrous oxide anaesthesia.
MedLine Citation:
PMID:  11284610     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: To compare the maintenance and recovery characteristics of sevoflurane and isoflurane anaesthesia in Malaysian patients. METHOD: This is a prospective, open labelled, randomized, controlled study. Sixty unpremedicated ASA I or II patients (aged 18-50 years), scheduled for elective breast lump excision were randomly allocated to receive either isoflurane or sevoflurane for the maintenance of anaesthesia following fentanyl and propofol intravenous induction. The systolic, diastolic, mean arterial blood pressure and heart rate were measured. The speed of recovery was measured by time to eye opening, time to following simple command, and time to correctly giving own names and address. The incidence of postoperative complication was also recorded. RESULTS: The trend of systolic blood pressure was significantly higher in the isoflurane group as compared to the sevoflurane group for the duration of anaesthesia (p < 0.001, by ANOVA for repeated measurement) but the trend of heart rate was similar for both groups. The recovery time was faster in the isoflurane group. [mean time of eye opening (SD) = 6.8 (2.2) vs 10.7 (4.4) min, p < 0.001; mean time of sticking tongue out (SD) = 7.9 (2.9) vs 11.5 (4.7) min, p < 0.01; mean time of giving own name (SD) = 7.8 (2.7) vs 11.8 (4.8) min, p < 0.001, mean time of giving own address (SD) = 8.4 (2.9) vs 12.0 (4.7) min, p < 0.01]. No major adverse effects were encountered postoperatively and the incidences of minor adverse effects were low in both groups. CONCLUSION: We concluded that sevoflurane is a safe alternative to isoflurane but in these short procedures, awakening time was surprisingly slower than after isoflurane.
C L Chiu; Y K Chan; G S Ong; A E Delilkan
Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Singapore medical journal     Volume:  41     ISSN:  0037-5675     ISO Abbreviation:  Singapore Med J     Publication Date:  2000 Nov 
Date Detail:
Created Date:  2001-04-03     Completed Date:  2001-04-26     Revised Date:  2009-11-03    
Medline Journal Info:
Nlm Unique ID:  0404516     Medline TA:  Singapore Med J     Country:  Singapore    
Other Details:
Languages:  eng     Pagination:  530-3     Citation Subset:  IM    
Department of Anaesthesia, University of Malaya Medical Centre, Kuala Lumpur, Malaysia.
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MeSH Terms
Anesthesia Recovery Period*
Anesthetics, Inhalation / pharmacology,  therapeutic use*
Blood Pressure / drug effects
Drug Therapy, Combination
Heart Rate / drug effects
Isoflurane / pharmacology,  therapeutic use*
Mastectomy, Segmental
Methyl Ethers / pharmacology,  therapeutic use*
Middle Aged
Monitoring, Intraoperative
Nitrous Oxide / pharmacology,  therapeutic use*
Prospective Studies
Time Factors
Reg. No./Substance:
0/Anesthetics, Inhalation; 0/Methyl Ethers; 10024-97-2/Nitrous Oxide; 26675-46-7/Isoflurane; 28523-86-6/sevoflurane

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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