Document Detail


A comparison of low- and high-impact forced exercise: effects of training paradigm on learning and memory.
MedLine Citation:
PMID:  22402029     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In this study we compared two types of forced exercise-a low impact paradigm to minimize stress, which included speeds up to 10 m/min and a stressful high impact paradigm, with speeds up to 21 m/min. 150 male C57BL/6J mice were randomly assigned to the low impact, high impact, or sedentary control conditions and were tested on the rotorod and Morris water maze (MWM) as indices of motor learning and spatial memory. We found that 5 weeks of stressful high speed forced exercise led to significant improvement in rotorod performance, as high impact runners outperformed both low impact runners and controls at 15 and 25 rpm speeds. These differences were the result of improved physical fitness due to exercise and likely do not reflect enhanced learning in these mice. In the MWM, 5 weeks of stressful high impact exercise led to significant impairment in spatial memory acquisition compared to low impact runners and controls. Low impact exercise for 10 weeks significantly improved retention of spatial memory compared to high impact exercise. Results suggested that these two paradigms produced different effects of forced exercise on learning and memory. The low impact paradigm led to some improvements, whereas the stressful high impact program caused significant impairment. Comparison of these two paradigms begins to address the window between the beneficial and detrimental effects of forced exercise, and have suggested a boundary of exercise intensity that leads to impairment in learning.
Authors:
John A Kennard; Diana S Woodruff-Pak
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural     Date:  2012-02-28
Journal Detail:
Title:  Physiology & behavior     Volume:  106     ISSN:  1873-507X     ISO Abbreviation:  Physiol. Behav.     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-05-09     Completed Date:  2012-09-04     Revised Date:  2013-06-26    
Medline Journal Info:
Nlm Unique ID:  0151504     Medline TA:  Physiol Behav     Country:  United States    
Other Details:
Languages:  eng     Pagination:  423-7     Citation Subset:  IM    
Copyright Information:
Copyright © 2012. Published by Elsevier Inc.
Affiliation:
Department of Psychology, Temple University, 1701 North 13th Street, Philadelphia, PA 19122, USA.
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MeSH Terms
Descriptor/Qualifier:
Analysis of Variance
Animals
Cerebellum / physiology
Endocrine System / physiology
Immunity / physiology
Learning / physiology*
Male
Maze Learning / physiology
Memory / physiology*
Mice
Mice, Inbred C57BL
Physical Conditioning, Animal / methods*,  physiology*
Postural Balance / physiology
Running / physiology
Swimming / physiology
Grant Support
ID/Acronym/Agency:
1 R01 AG021925/AG/NIA NIH HHS; 1 R01 AG023742/AG/NIA NIH HHS; R01 AG023742-05/AG/NIA NIH HHS
Comments/Corrections

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