| A comparison of kaolin-activated versus nonkaolin-activated thromboelastography in native and citrated blood. | |
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MedLine Citation:
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PMID: 18685432 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Thromboelastography can be performed with native or citrated blood (a surrogate to native blood in healthy controls, surgical and cirrhotic patients). Activators such as kaolin are increasingly used to reduce the time to trace generation. To compare kaolin-activated thromboelastography with nonkaolin-activated thromboelastography of native and citrated blood in patients with liver disease, patients undergoing treatment with warfarin or low-molecular weight heparin and healthy volunteers. We studied thromboelastography parameters in 21 healthy volunteers (group 1) and 50 patients, including 20 patients with liver cirrhosis with a nonbiliary aetiology (group 2), 10 patients with primary biliary cirrhosis or primary sclerosing cholangitis (group 3), 10 patients on warfarin treatment (group 4) and 10 patients with enoxaparin prophylaxis (group 5). Thromboelastography was performed using four methods: native blood (kaolin-activated and nonkaolin-activated) and citrated blood (kaolin-activated and nonkaolin-activated). For all thromboelastography parameters, correlation was poor (Spearman correlation coefficient < 0.70) between nonkaolin-activated and kaolin-activated thromboelastography, for both citrated and native blood. In healthy volunteers, in patients with liver disease and in those receiving anticoagulant treatment, there was a poor correlation between nonkaolin-activated and kaolin-activated thromboelastography. Kaolin-activated thromboelastography needs further validation before routine clinical use in these settings, and the specific methodology must be considered in comparing published studies. |
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Authors:
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Ulrich Thalheimer; Christos K Triantos; Dimitrios N Samonakis; Andrea Zambruni; Marco Senzolo; Gioacchino Leandro; David Patch; Andrew K Burroughs |
Publication Detail:
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Type: Comparative Study; Journal Article; Validation Studies |
Journal Detail:
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Title: Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis Volume: 19 ISSN: 0957-5235 ISO Abbreviation: Blood Coagul. Fibrinolysis Publication Date: 2008 Sep |
Date Detail:
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Created Date: 2008-08-07 Completed Date: 2008-11-24 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9102551 Medline TA: Blood Coagul Fibrinolysis Country: England |
Other Details:
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Languages: eng Pagination: 495-501 Citation Subset: IM |
Affiliation:
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Sheila Sherlock Hepatobiliarypancreatic and Liver Transplantation Unit, Royal Free Hospital, London, UK. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Anticoagulants / pharmacology* Artifacts Blood Specimen Collection / methods* Cholangitis, Sclerosing / blood Citrates / pharmacology* Enoxaparin / pharmacology, therapeutic use False Positive Reactions Female Hepatitis, Viral, Human / blood Humans International Normalized Ratio Kaolin / pharmacology* Liver Cirrhosis / blood Liver Cirrhosis, Biliary / blood Liver Diseases / blood* Male Middle Aged Reference Standards Reproducibility of Results Sensitivity and Specificity Thrombelastography / methods*, standards Warfarin / pharmacology, therapeutic use |
| Chemical | |
Reg. No./Substance:
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0/Anticoagulants; 0/Citrates; 0/Enoxaparin; 1332-58-7/Kaolin; 18996-35-5/sodium citrate; 81-81-2/Warfarin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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