| A comparison of isosorbide mononitrate and misoprostol cervical ripening before suction evacuation. | |
| | |
MedLine Citation:
|
PMID: 12962946 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVE: To compare the efficacy of a nitric oxide donor (isosorbide mononitrate) and a prostaglandin E1 analogue (misoprostol) for cervical priming before suction termination of pregnancy. METHODS: This was a randomized, double blind, placebo-controlled trial. One hundred twenty-six healthy women requesting termination of pregnancy between 9 and 12 weeks' gestation were recruited. Women were randomized into three groups: control, isosorbide mononitrate, and misoprostol. All women were given moistened intravaginal study drugs (placebo, 40 mg of isosorbide mononitrate, or 400 microg of misoprostol) 4-6 hours before suction evacuation. Side effects were assessed 3 hours after drug administration. The cervical dilatation and the cumulative force required to dilate the cervix to 8 mm were measured by a cervical tonometer before suction evacuation. Operative blood loss was measured after sieving off the products of gestation. RESULTS: There were no differences in the baseline cervical dilatation, cumulative force, and operative blood loss between the isosorbide mononitrate and placebo groups. However, women in the misoprostol group had a significantly greater cervical dilatation, required less cumulative force, and had less blood loss than women in the isosorbide mononitrate or control group. The majority (more than 80%) of women in all three groups found their cervical priming agents acceptable. CONCLUSION: Intravaginal isosorbide mononitrate was less effective than misoprostol in cervical ripening before suction termination of pregnancy. |
| | |
Authors:
|
C F Ivy Li; C W Carina Chan; P C Ho |
Related Documents
:
|
17826436 - Transabdominal cerclage after comprehensive evaluation of women with previous unsuccess... 10844796 - Spinal angulation after anterior discectomy and graftless fusion. 17363446 - In vivo characterization of the mechanics of human uterine cervices. 463976 - The effect of pregnancy on the cervical squamocolumnar junction in patients with abnorm... 9699416 - Myosin isoforms in uterine smooth muscle during pregnancy in rat. 9706656 - Prenatal diagnosis of a transient myeloproliferative disorder in trisomy 21. |
Publication Detail:
|
Type: Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Obstetrics and gynecology Volume: 102 ISSN: 0029-7844 ISO Abbreviation: Obstet Gynecol Publication Date: 2003 Sep |
Date Detail:
|
Created Date: 2003-09-09 Completed Date: 2003-10-15 Revised Date: 2009-10-26 |
Medline Journal Info:
|
Nlm Unique ID: 0401101 Medline TA: Obstet Gynecol Country: United States |
Other Details:
|
Languages: eng Pagination: 583-8 Citation Subset: AIM; IM |
Affiliation:
|
Department of Obstetrics & Gynaecology, The University of Hong Kong, Queen Mary Hospital, Hong Kong, People's Republic of China. ivyli99@hotmail.com |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Abortion, Induced
/
methods* Adolescent Adult Analysis of Variance Cervical Ripening / drug effects Double-Blind Method Female Humans Isosorbide Dinitrate / analogs & derivatives*, therapeutic use* Middle Aged Misoprostol / therapeutic use* Pregnancy Pregnancy Outcome Pregnancy Trimester, First Probability Sensitivity and Specificity Statistics, Nonparametric Vacuum Curettage / methods |
| Chemical | |
Reg. No./Substance:
|
16051-77-7/isosorbide-5-mononitrate; 59122-46-2/Misoprostol; 87-33-2/Isosorbide Dinitrate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Influence of hormonal contraceptives on the immune cells and thickness of human vaginal epithelium.
Next Document: Persistent unilocular ovarian cysts in a general population of postmenopausal women: is there a plac...