Document Detail

A comparison of the iron-clearing properties of 1,2-dimethyl-3-hydroxypyrid-4-one, 1,2-diethyl-3-hydroxypyrid-4-one, and deferoxamine.
MedLine Citation:
PMID:  1558978     Owner:  NLM     Status:  MEDLINE    
A comparative study of the iron-clearing properties of subcutaneously (SC) administered deferoxamine (DFO) with those of orally administered 1,2-dimethyl-3-hydroxypyrid-4-one (CP20) and 1,2-diethyl-3-hydroxypyrid-4-one (CP94) is presented. The studies were performed in both a non-iron-overloaded, bile duct-cannulated rat model and an iron-loaded Cebus monkey model. All three drugs performed well in the rodent, promoting the excretion of iron in both the urine and the bile, with total iron output efficiencies of 2.8%, 1.2%, and 7.1%, respectively. The efficiency of DFO increased slightly in the Cebus model, while that of the hydroxypyridones was essentially the same in the monkey, with total iron output efficiencies of 5.5%, 2.1%, and 7.4%, respectively. Iron balance studies showed that both DFO and CP94 were able to maintain the animals in a negative iron balance, while CP20 had little impact.
R J Bergeron; R R Streiff; J Wiegand; G Luchetta; E A Creary; H H Peter
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Blood     Volume:  79     ISSN:  0006-4971     ISO Abbreviation:  Blood     Publication Date:  1992 Apr 
Date Detail:
Created Date:  1992-05-14     Completed Date:  1992-05-14     Revised Date:  2013-06-03    
Medline Journal Info:
Nlm Unique ID:  7603509     Medline TA:  Blood     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1882-90     Citation Subset:  AIM; IM    
University of Florida, College of Pharmacy, Department of Medical Chemistry, Gainesville 32610.
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MeSH Terms
Bile / metabolism
Deferoxamine / metabolism
Feces / chemistry
Iron / metabolism*,  urine
Iron Chelating Agents / metabolism*
Pyridones / metabolism*,  toxicity
Rats, Inbred Strains
Reg. No./Substance:
0/Iron Chelating Agents; 0/Pyridones; 115900-75-9/1,2-diethyl-3-hydroxypyridin-4-one; 2BTY8KH53L/deferiprone; 70-51-9/Deferoxamine; 7439-89-6/Iron

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