| A comparison of the iron-clearing properties of 1,2-dimethyl-3-hydroxypyrid-4-one, 1,2-diethyl-3-hydroxypyrid-4-one, and deferoxamine. | |
| | |
MedLine Citation:
|
PMID: 1558978 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
A comparative study of the iron-clearing properties of subcutaneously (SC) administered deferoxamine (DFO) with those of orally administered 1,2-dimethyl-3-hydroxypyrid-4-one (CP20) and 1,2-diethyl-3-hydroxypyrid-4-one (CP94) is presented. The studies were performed in both a non-iron-overloaded, bile duct-cannulated rat model and an iron-loaded Cebus monkey model. All three drugs performed well in the rodent, promoting the excretion of iron in both the urine and the bile, with total iron output efficiencies of 2.8%, 1.2%, and 7.1%, respectively. The efficiency of DFO increased slightly in the Cebus model, while that of the hydroxypyridones was essentially the same in the monkey, with total iron output efficiencies of 5.5%, 2.1%, and 7.4%, respectively. Iron balance studies showed that both DFO and CP94 were able to maintain the animals in a negative iron balance, while CP20 had little impact. |
| | |
Authors:
|
R J Bergeron; R R Streiff; J Wiegand; G Luchetta; E A Creary; H H Peter |
Related Documents
:
|
10227068 - Effect of some psychotropic drugs on the activated macrophage-induced luminol-dependent... 6619738 - Further studies on the effect of niridazole on urinary and biliary excretion of copper. 2842038 - Adriamycin-induced free radical formation in the perfused rat heart: implications for c... 23569078 - Studies on stercuia gum formulations in the form of osmotic core tablet for colon-speci... 21426138 - Drug discovery and development for spinal muscular atrophy: lessons from screening appr... 22875288 - Cocaine-induced vasculitis: clinical and immunological spectrum. |
Publication Detail:
|
Type: Comparative Study; Journal Article |
Journal Detail:
|
Title: Blood Volume: 79 ISSN: 0006-4971 ISO Abbreviation: Blood Publication Date: 1992 Apr |
Date Detail:
|
Created Date: 1992-05-14 Completed Date: 1992-05-14 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 7603509 Medline TA: Blood Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 1882-90 Citation Subset: AIM; IM |
Affiliation:
|
University of Florida, College of Pharmacy, Department of Medical Chemistry, Gainesville 32610. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Bile / metabolism Cebus Deferoxamine / metabolism Feces / chemistry Iron / metabolism*, urine Iron Chelating Agents / metabolism* Kinetics Male Pyridones / metabolism*, toxicity Rats Rats, Inbred Strains |
| Chemical | |
Reg. No./Substance:
|
0/Iron Chelating Agents; 0/Pyridones; 115900-75-9/1,2-diethyl-3-hydroxypyridin-4-one; 30652-11-0/deferiprone; 70-51-9/Deferoxamine; 7439-89-6/Iron |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Decreased concentrations of tumor necrosis factor-alpha in supernatants of monocytes from homozygote...
Next Document: Ultrastructure of the mammalian pinealocyte under natural and experimental conditions: quantitative ...