| A comparison of intrathecal analgesia with fentanyl or sufentanil after total hip replacement. | |
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MedLine Citation:
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PMID: 10735799 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We designed this study to compare the postoperative analgesic effects of intrathecal fentanyl and sufentanil, the end points being onset, quality, and duration of action. A total of 42 geriatric patients, scheduled for elective total hip replacement under continuous spinal anesthesia, were randomized in two double-blinded groups as soon as they experienced a pain score higher than 3 of 10 on the visual analog scale in the recovery room. Either 7.5 microg sufentanil or 40 microg fentanyl in 2 mL normal saline were intrathecally administered. Pain scores, rescue analgesia (ketorolac and morphine), and adverse effects (respiratory depression, postoperative nausea and vomiting, and itching) were recorded for 24 h after surgery. In both groups, comparing sufentanil to fentanyl, the time to a pain score <3 (9 +/- 9 vs 11 +/- 8 min), the time to the lowest pain score (18 +/- 6 vs 20 +/- 15 min), and the time to the first systemic analgesic intervention for a pain score >3 (241 +/- 102 vs 214 +/- 120 min) were comparable as were the analgesic requirements during the first 24 h. We conclude that, after total hip replacement, both lipid soluble opioids produce excellent analgesia with comparable onset, duration of action, and low incidence of minor adverse effects. Implications: We compared the postoperative analgesic properties of 40 microg intrathecal fentanyl and 7.5 microg sufentanil after total hip replacement. Both opioids provided satisfactory analgesia, with comparable onset (11 +/- 8 vs 9 +/- 9 min) and duration of action (214 +/- 120 vs 241 +/- 102 min), as well as low incidence of minor side effects. |
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Authors:
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R Fournier; E Van Gessel; A Weber; Z Gamulin |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: Anesthesia and analgesia Volume: 90 ISSN: 0003-2999 ISO Abbreviation: Anesth. Analg. Publication Date: 2000 Apr |
Date Detail:
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Created Date: 2000-04-20 Completed Date: 2000-04-20 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 1310650 Medline TA: Anesth Analg Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 918-22 Citation Subset: AIM; IM |
Affiliation:
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Department of Anesthesiology, University Hospital of Geneva, Geneva, Switzerland. Roxane.Fournier@hcuge.ch |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aged, 80 and over Analgesics, Opioid / administration & dosage* Arthroplasty, Replacement, Hip* Double-Blind Method Female Fentanyl / administration & dosage*, adverse effects Humans Injections, Spinal Male Pain, Postoperative / drug therapy* Sufentanil / administration & dosage*, adverse effects |
| Chemical | |
Reg. No./Substance:
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0/Analgesics, Opioid; 437-38-7/Fentanyl; 56030-54-7/Sufentanil |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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