Document Detail


A comparison of intraperitoneal injection and oral gavage in the micronucleus test with mitomycin C in mice.
MedLine Citation:
PMID:  2501679     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Intraperitoneal (i.p.) injection and oral (p.o.) gavage were evaluated in the mouse micronucleus test with mitomycin C (MMC). The tests were carried out in 2 laboratories with the MS/Ae and CD-1 mouse strains. On the basis of a small-scale acute toxicity study and a pilot experiment, the full-scale micronucleus test was performed with a 24-h sampling time at doses of 1, 2, 4, and 8 mg/kg for both treatment routes. In both strains, a clear positive dose-response relation was shown by both routes. Although the frequency of micronucleated polychromatic erythrocytes (MNPCEs) was higher with i.p. on a mg/kg basis, this tendency was reversed when dose was expressed as a percentage of the LD50.
Authors:
S Sato; N Inui; Y Ikeda; Y Hiraga
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Mutation research     Volume:  223     ISSN:  0027-5107     ISO Abbreviation:  Mutat. Res.     Publication Date:  1989 Aug 
Date Detail:
Created Date:  1989-08-25     Completed Date:  1989-08-25     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0400763     Medline TA:  Mutat Res     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  387-90     Citation Subset:  IM    
Affiliation:
Toxicology Research Laboratories, Japan Tobacco Inc., Kanagawa.
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MeSH Terms
Descriptor/Qualifier:
Administration, Oral
Animals
Injections, Intraperitoneal
Lethal Dose 50
Male
Mice
Micronucleus Tests*
Mitomycin
Mitomycins / administration & dosage*,  toxicity
Mutagens / administration & dosage*
Pilot Projects
Chemical
Reg. No./Substance:
0/Mitomycins; 0/Mutagens; 50-07-7/Mitomycin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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